TAILIEUCHUNG - CLINICAL PHARMACOLOGY 2003 (PART 22)

Antiepilepsy drugs: principles of management; withdrawal of therapy; pregnancy; teratogenic effects; epilepsy in children; status epilepticus • Individual drugs: carbamazepine, phenytoin, sodium valproate, lamotrigine, vigabatrin, gabapentin, clonazepam, topiramate, levetiracetam. • Parkinsonism Objectives of therapy Drug therapy; problems of long-term treatment • Other disorders of movement • Tetanus cortical neurons simultaneously (primary generalised seizure). Bromide (1857) was the first drug to be used for the treatment of epilepsy, but it is now obsolete. Phenobarbital, introduced in 1912, controlled patients resistant to bromides. The next success was the discovery in 1938 of phenytoin (a hydantoin) which is structurally related to the. | SECTION 4 Epilepsy parkinsonism and allied conditions SYNOPSIS Antiepilepsy drugs principles of management withdrawal of therapy pregnancy teratogenic effects epilepsy in children status epilepticus Individual drugs carbamazepine phenytoin sodium valproate lamotrigine vigabatrin gabapentin clonazepam topiramate levetiracetam. Parkinsonism Objectives of therapy Drug therapy problems of long-term treatment Other disorders of movement Tetanus cortical neurons simultaneously primary generalised seizure . Bromide 1857 was the first drug to be used for the treatment of epilepsy but it is now obsolete. Phenobarbital introduced in 1912 controlled patients resistant to bromides. The next success was the discovery in 1938 of phenytoin a hydantoin which is structurally related to the barbiturates. Since then many other drugs have been discovered but phenytoin still remains a drug of choice in the treatment of major epilepsy. Over the past ten years there has been a dramatic increase in the number of new anticonvulsant drugs vigabatrin gabapentin lamotrigine topiramate oxcarbazepine levetiracetam but none has been shown to be superior to the major standard anticonvulsants phenytoin carbamazepine and sodium valproate . Antiepilepsy drugs Epilepsy affects 5-10 per 1000 of the general It is due to sudden excessive depolarisation of some or all cerebral neurons. This may remain localised focal seizure or may spread to cause a secondary generalised seizure or affect all 1 Some people with epilepsy make pilgrimages to Terni Italy to seek intercession from Saint Valentine to relieve their condition. There was more than one Saint Valentine and it is unclear if he was also the patron saint of lovers. MODE OF ACTION Antiepilepsy anticonvulsant drugs inhibit the neuronal discharge or its spread and do so in one or more of three ways 1. Reducing cell membrane permeability to ions particularly the voltage-dependent sodium channels which are responsible for the inward current .

• Y học thường thức
• Epilepsy
• parkinsonism
• allied conditions
• clinical pharmacology
• sách học ngành dược
• dược lý lâm sàng
• tài liệu học dược sĩ
• bảo quản thuốc
• BMC Veterinary Research
• Wild cat
• Idiopathic epilepsy
• Juvenile epilepsy
• Benign epilepsy
• ABC of epilepsy
• Classifying the condition
• Making the diagnosis
• Clinical examination
• Managing the drug treatment
• Repeated seizures
• Non drug treatments including epilepsy surgery
• BMC Pediatrics
• Epileptic attack
• School absenteeism
• Childhood epilepsy
• Epilepsy in Ethiopia
• Health related quality
• Life measure for children
• Children with epilepsy
• Parent proxy CHEQOL 25
• Children with epilepsy aged 8–15 years
• Quality of life
• Canine epilepsy
• Border Collies
• Toll like receptor 4
• Structural epilepsy
• Inflammatory signaling
• động kinh
• bệnh học và điều trị
• y học cổ truyền
• đông y trị bệnh
• bài giảng bệnh học
• Current practice of clinical electroencephalography
• Pediatric epilepsy syndromes
• EEG in adult epilepsy
• EEG voltage topography
• Subdural electrode corticography
• Evoked potentials overview
• Calcium ion
• Oxidative stress
• Transient receptor potential channels
• Etiology of epilepsy
• reactive oxygen species
• Endothelial progenitor cells
• Neuronal damage
• Therapeutic potential
• Rat model of epilepsy
• Role of autophagy
• Mixed method systematic
• Epilepsy specific
• Psycho social factors
• Healthcare contexts
• Negative healthcare
• Temporal lobe epilepsy
• Pilocarpine neurons
• Glucose uptake
• Hippocampal glucose hypometabolism
• Glial fibrillary acidic protein
• Benign childhood epilepsy
• Centrotemporal spikes
• Depression Self Rating Scale for Children
• Spike wave index
• Adverse event following immunization
• Vaccine safety
• Pre existing epilepsy
• Relative risk
• Anti epileptic drugs
• Frequently sub optimal
• Multi therapy
• Epilepsy symptoms
• BMC Anesthesiology
• Epilepsy surgery
• Pediatric neuroanesthesia
• Pediatric neurosurgery
• Intraoperative blood loss
• Toxocara canis
• Toxoplasma gondii
• Western blotting
• Mid region
• Toxoplasmosis in children
• Serum glucоse level
• Aan seizures cause glycemic disorder
• Glycemic disorder in children
• Journal of clinical Medicine