TAILIEUCHUNG - Serum apolipoprotein B to apolipoprotein A-I ratio is an independent predictor of liver metastasis from locally advanced rectal cancer in patients receiving neoadjuvant chemoradiotherapy plus surgery

The ratio of serum apolipoprotein B (apoB) to apolipoprotein A-I (apoAI) had been reported as a prog‑ nostic factor in colorectal cancer. This retrospective study aimed to assess the implication of apoB-to-apoAI ratio in predicting liver metastasis from rectal cancer (RC). | Chen et al. BMC Cancer 2022 22 7 https s12885-021-09101-y RESEARCH Open Access Serum apolipoprotein B to apolipoprotein A-I ratio is an independent predictor of liver metastasis from locally advanced rectal cancer in patients receiving neoadjuvant chemoradiotherapy plus surgery Chen Chen1 2 Wei Yi3 Zhi fan Zeng1 2 Qiao xuan Wang1 2 Wu Jiang2 4 Yuan hong Gao1 2 and Hui Chang1 2 Abstract Background The ratio of serum apolipoprotein B apoB to apolipoprotein A-I apoAI had been reported as a prog nostic factor in colorectal cancer. This retrospective study aimed to assess the implication of apoB-to-apoAI ratio in predicting liver metastasis from rectal cancer RC . Methods The clinical data of 599 locally advanced RC patients treated with chemoradiotherapy followed by surgery were reviewed. Serum apoAI apoB and apoB-to-apoAI ratio were analyzed for their correlation with the liver-metasta sis-free other-metastasis-free and overall survivals together with the pretreatment and postsurgical pathoclinical fea tures of the patients. Univariate and multivariate survival analyses were realized through the Kaplan-Meier approach and Cox model respectively. Hazard ratios HRs and 95 confidence intervals CIs were calculated for independent predictors. Results Carbohydrate antigen 19 9 U ml apoB-to-apoAI ratio tumor regression grade 5 3 pT4 and pN stage emerged as independent predictors of poorer liver-metastasis-free survival. The hazard ratios were 95 CI 95 CI 95 CI 95 CI and 95 CI respectively. Except apoB-to-apoAI ratio the other 4 factors were also independent predictors of poorer other-metastasis-free and overall survivals. And the independent predictors of poorer overall survival also included age 67 years old distance to anal verge Chen et al. BMC Cancer 2022 22 7 Page 2 of 8 time of merely months. Yet the figure could rise to monoclonal antibody iv .

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• BMC Cancer
• Rectal cancer
• Liver metastasis
• Serum apolipoprotein B
• Predicting liver metastasis
• Confidence intervals
• Cancer patient pathways
• Colorectal cancer
• Lung cancer
• Breast cancer
• Prostate cancer
• Ovarian cancer
• Cancer detection
• Ovarian cancer symptoms
• Ovarian cancer signs
• Ovarian cancer tests
• Cancer biomarkers
• Pediatric cancer
• Familial cancer predisposition
• Hereditary cancer syndrome
• Genetic cancer susceptibility
• Advanced cancer
• Biliary tract cancer
• Multimodal intervention
• Pancreatic cancer
• Physical activity
• Breast cancer screening
• Familial breast cancer
• Young breast cancer survivors
• High risk relatives
• Randomized trial
• Childhood cancer
• Childhood cancer survivor
• Thyroid cancer screening
• Secondary cancer
• Cancer screening
• Community awareness
• Cancer education
• Cervical cancer
• Prior cancer
• Cancer survivors
• Cancer registry
• Second cancer
• Surgical oncology
• Cancer imaging
• Radiation oncologists
• Medical oncologists
• Oesophagogastric cancer
• Liver cancer
• Hepatobiliary cancer
• Multidisciplinary rehabilitation
• EGFR mutation
• Family history of cancer
• Inherited susceptibility
• Cancer predisposition genes
• Lung cancer aetiology
• Cancer stem cells
• Oct4 overexpressing lung cancer
• Human lung cancer xenograft model
• Disease free survivals
• Cancer hallmarks
• Cancer genesis
• Defiant disease
• Mutational signature
• Cancer diagnosis
• Cancer genomics
• Molecular medicine
• Whole genome sequencing
• Cancer susceptibility gene
• Breast cancer prognosis
• Next generation sequencing
• Quality of care
• Quality indicators
• Shifting cancer care
• German cancer society
• Colorectal cancer screening
• Stomach cancer screening
• Lung cancer survivor
• Physician recommendation
• Total number of lymph nodes
• Lymph node ratio
• Left colon cancer
• Right colon cancer
• Overall survival
• Cumulative incidence
• Esophageal cancer
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• Young onset
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• Risk factor
• Early detection of cancer
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• Population based specialized registry
• Gastric cancer survival
• Gastric cancer clinical characteristics
• Gastric cancer pathological characteristics
• Lung Cancer Screening
• Racial disparities
• Lung Cancer diagnosis
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• Second primary colorectal cancer
• Standardized incidence ratio
• Left sided colon cancer
• Right sided colon cancer
• Quality of cancer care
• Population based study