TAILIEUCHUNG - Evaluation of results of conformal concurrent chemoradiotherapy at the dose of 50.5 Gy in the treatment of non surgical esophageal cancer at 103 Military Hospital

Objectives: To evaluate the efficacy and adverse effects of conformal concurrent chemoradiotherapy at the dose of Gy in non-surgical esophageal cancer patient at 103 Military Hospital. Subjects and methods: A cross-sectional and prospective study was performed in 66 patients who were diagnosed with non-surgical esophageal cancer at 103 Military Hospital from January 2015 to June 2018. | T¹p chÝ y - d−îc häc qu©n sù sè 1-2019 EVALUATION OF RESULTS OF CONFORMAL CONCURRENT CHEMORADIOTHERAPY AT THE DOSE OF Gy IN THE TREATMENT OF NON-SURGICAL ESOPHAGEAL CANCER AT 103 MILITARY HOSPITAL Tran Viet Tien1; Tran Van Ton1; Pham Thi Hoan1 SUMMARY Objectives: To evaluate the efficacy and adverse effects of conformal concurrent chemoradiotherapy at the dose of Gy in non-surgical esophageal cancer patient at 103 Military Hospital. Subjects and methods: A cross-sectional and prospective study was performed in 66 patients who were diagnosed with non-surgical esophageal cancer at 103 Military Hospital from January 2015 to June 2018. Results: The complete response rate was , the partial response rate was . The overall survival rate after 18 months was , the survival rate after 18 months with stages II, III and IV was 100%, , , respectively; common adverse effects were eosinophilia I (), uncommon adverse effects were complications of pneumonia (), esophageal fistula (). Conclusion: Conformal concurrent chemoradiotherapy at the dose of Gy and PF therapy significantly improves clinical symptoms, prolongs survival time, reduce complications and adverse effects. * Keywords: Esophageal cancer; Concurrent chemoradiotherapy; 3D conformal radiation therapy. INTRODUCTION According to Globocan 2012, esophageal cancer is the eighth most common cancer in the world and ranks third in gastrointestinal cancers after stomach cancer and colon cancer [3]. For non-surgical esophageal cancer, concurrent chemoradiotherapy is highly effective in significantly improving the clinical symptoms and prolonging the patient's life time. In Vietnam, there are several studies about chemoradiotherapy in the treatment of esophageal cancer, such as the study of Han Thanh Binh in 2004, Nguyen Duc Loi in 2015, but these studies were limited to 2D radiotherapy and 60 Gy high dose radiation therapy [1, 2]. Minsky's RTOG 94-05 in 2002 .

• Y khoa - Dược
• Esophageal cancer
• Concurrent chemoradiotherapy
• 3D conformal radiation therapy
• Non surgical esophageal cancer
• 103 Military Hospital
• BMC Cancer
• Esophageal fistula
• Risk factor
• Multivariate logistic regression analysis
• Esophageal adenocarcinoma
• Esophageal squamous cell carcinoma
• Cox’s proportional hazards analysis
• Esophageal cancer surgery
• Surgical procedures performed
• Squamous cell carcinoma
• Tissue microarray
• RBM3 expression
• Cancer types
• Esophageal epithelium
• Neoadjuvant therapy
• Cyclooxygenase 2 inhibition
• Humans suggest
• Esophageal cancer risk
• Paclitaxel carboplatin
• Gastro esophageal junctional cancer
• Platinum analogue
• Angiogenic factors
• Despite multimodal therapy esophageal cancer
• Angiogenic cytokine
• Multiplex immunoassay
• Epidermal growth factor receptor
• Meta analysis
• Metastatic esophageal cancer
• Standard treatment
• Upper third esophageal cancer
• Intensity modulated radiation therapy
• Intensitymodulated radiation
• Esophageal cancer patients
• Thoracoscopic esophagectomy
• Results of thoracoscopic esophagectomy
• 103 Military Hospital 103
• Palliative treatment
• Inoperable esophageal cancer
• Partially covered self expanding metallic stents
• Quality of life
• Comparative effectiveness
• Prior systematic
• 18FDG PET CT simulation
• 3D conformal radiotherapy
• CT simulation in 3D conformal
• Chemo radiotherapy for esophageal cancer
• Definitive chemoradiation
• Acute toxicity
• Irresectable esophageal cancer
• Esophageal neoplasms
• Response evaluation criteria in solid tumors
• Mental disorder
• Gastric cancer
• Cohort study
• Cancer treatment
• Waiting time
• Narrow band imaging
• Head and neck cancer
• Second primary cancer
• Whole exome sequencing
• Fastq2vcf modified
• Generation sequencing
• Lymph node metastases
• Esophageal carcinoma
• Invasion depth
• Neoadjuvant treatment
• Digestive system
• RAS oncogene family like 6
• Several cancers
• Prognostic factor
• Controlling nutritional status
• Tumor development
• PHLPP2 proteins
• Aurora A
• Chemoradiation therapy
• DNA repair