TAILIEUCHUNG - Ebook Sarcoma of the female genitalia (Vol 1): Part 2

The subject matter of volume 1 of the 2-volumes-handbook focusses on leiomyosarcoma, low-grade and high-grade endometrial sarcoma and undifferentiated uterine sarcoma of the whole female genitalia. The book aims to identify and provide diagnostic and therapeutic guidance. The listed tumor entities also constitute a particular diagnostic challenge for pathologists that contains numerous pitfalls and difficulties. | Günter Köhler, Katja Evert, Marek Zygmunt and Matthias Evert 3 Endometrial stromal tumors – endometrial stromal nodule, endometrial stromal tumor with sex cord-like elements (ESTSCLE), uterine tumor resembling ovarian sex-cord tumor (UTROSCT) and similar tumors Introduction The current WHO Classification (36) divides EST and similar neoplasms into ESN, LGESS, HG-ESS and UUS. UTROSCT also belong to the EST family of tumors. ESN are benign stromal tumors. There are special forms of EST with different types of differentiation, like the endometrial stromal tumor with endometrioid glands, mixed endometrial stromal tumors and smooth muscle tumors as well as endometrial stromal tumors with sex cord-like elements (ESTSCLE), and uterine tumors resembling ovarian sex-cord tumor (UTROSCT). Uterine stromal sarcomas (LG-ESS, HG-ESS, UUS) belong to the family of pure homologous sarcomas and are discussed in separate chapters (Chapters 4 and 5). Endometrial stromal nodule Uterine endometrial stromal nodule General, pathogenesis, pathological-anatomical features ESN is a benign EST with histological features unambiguously reminiscent of endometrial stroma in the proliferation phase. Overall, ESN are only very rarely diagnosed, accounting for only 3 % of all EST in the DKSM database (25). ESN have been observed to arise in women aged 23–86. The majority of patients are premenopausal, with a median and mean age of 47 resp. 53 years. It can already be deduced from this age distribution that ESN share an epidemiologic relationship with LG-ESS, which, according to the DKSM data, arise in patients aged 18 to 80 years. Median age of patients with LG-ESS is 46 years, suggesting that, like ESN, the majority of such tumors arise in premenopausal women (25). These two types of neoplasm in fact share clear pathogenetic commonalities. On the one hand, the differences between the two in terms of their microscopic features are more gradual than abrupt. Both LG-ESS and ESN exhibit .

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• Sarcoma of the female genitalia
• The female genitalia
• Endometrial stromal tumors
• Endometrial stromal nodule
• Similar tumors
• High grade endometrial stromal sarcoma
• Primary surgery
• Cellular leiomyoma
• Disseminated peritoneal leiomyomatosis
• Benign metastasizing leiomyoma