TAILIEUCHUNG - Study on the concentration of urinary neutrophil gelatinase associated lipocalin in patients occuring acute kidney failure in intensive care unit

Objective: To evaluate urinary neutrophil gelatinase-associated lipocalin (NGAL) concentration and its relation with causes, categories, stages and biochemical indexes of acute kidney injury (AKI) patients. Subjects and methods: A prospective, cross-sectional study in 121 patients with AKI who admitted to a general Intensive Care Unit (ICU), Trungvuong Hospital, Hochiminh City from 12 - 2013 to 01 - 2017 and a control group of 51 healthy people. Urinary NGAL had done in all 116 patients and healthy people. | Journal of military pharmaco-medicine no7-2017 STUDY ON THE CONCENTRATION OF URINARY NEUTROPHIL GELATINASE - ASSOCIATED LIPOCALIN IN PATIENTS OCCURING ACUTE KIDNEY FAILURE IN INTENSIVE CARE UNIT Pham Ngoc Huy Tuan*; Nguyen Trung Kien**; Le Viet Thang** SUMMARY Objective: To evaluate urinary neutrophil gelatinase-associated lipocalin (NGAL) concentration and its relation with causes, categories, stages and biochemical indexes of acute kidney injury (AKI) patients. Subjects and methods: A prospective, cross-sectional study in 121 patients with AKI who admitted to a general Intensive Care Unit (ICU), Trungvuong Hospital, Hochiminh City from 12 - 2013 to 01 - 2017 and a control group of 51 healthy people. Urinary NGAL had done in all 116 patients and healthy people. Results: All of the AKI patients (100%) had urinary NGAL elevation. The average concentration of urinary NGAL in our study group ( ng/mL) was significantly higher than in control group ( ng/mL) with p In our study, sepsis was the most common causes with the proportion of . There was no significant difference between these causes with p > . Our result was similar to study of Vaidya : there was no significant difference between urinary NGAL concentration and several causes of AKI in these studies (p > ) [10], but was different with other studies of Di Nardo M and Geus (there was a significant higher concentration of urinary NGAL in septic AKI patients than nonseptic AKI patients with p < [4, 6]. Lipoproteins also have strong affinity for Toll-like receptors (TLRs) that trigger an innate immune response. Therefore, it could be postulated that these circulating ligands which are linked to tubular epithelial TLR activation are responsible for the increased uNGAL concentrations that we observed in patients who had sepsis, but showed no increases in their serum creatinine levels. However, recent studies in patients with sepsis, septic shock, and systemic inflammatory .

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