TAILIEUCHUNG - Ebook Hematology, immunology and infectious disease expert consult (second edition): Part 2

(BQ) Part 2 book "Hematology, immunology and infectious disease expert consult" presents the following contents: Diagnosis, treatment, and considerations on vaccine mediated prevention; neonatal T cell immunity and its regulation by innate immunity and dendritic cells; probiotics for the prevention of necrotizing enterocolitis in preterm neonates; breast milk and viral infection; probiotics for the prevention of necrotizing enterocolitis in preterm neonates,. Invite you to consult. | CHAPTER 11 CMV Diagnosis Treatment and Considerations on Vaccine-Mediated Prevention Shannon A. Ross MD MSPH and Suresh B. Boppana MD The Virus Epidemiology Transmission of CMV Pathogenesis Immune Response to Infection Pathogenesis of Congenital Infection Pathology Clinical Manifestations Laboratory Diagnosis Diagnosis During Pregnancy Treatment Prognosis Prevention The Virus CMV human herpesvirus 5 is the largest and most complex member of the family of herpesviruses. The virion consists of three regions the capsid containing the double-stranded DNA viral genome the tegument and the envelope. The viral genome consists of more than 235 kilobase pairs which contain more than 252 open reading The complexity of the genetic makeup of CMV confers extensive genetic variability among strains. Restriction fragment length polymorphism analysis as well as DNA sequence analysis has demonstrated that no two clinical isolates are The viral tegument contains viral proteins that function to maintain the structural integrity of the virion are important for assembly of an infectious particle and are involved in regulatory activities in the replicative cycle of the virus. The viral envelope contains eight glycoproteins that have been described as well as an unknown number of additional proteins. The most abundant envelope glycoproteins are the gM gN gB and gH gL gO complexes all of which are important for virus infectivity. In addition gB gH and gM gN have been shown to induce an antibody response in the infected host and are major components of the protective response of the infected host to the 4 Epidemiology Cytomegalovirus infections have been recognized in all human populations. CMV is acquired early in life in most populations with the exception of people in the economically well developed countries of northern Europe and North America. 171 172 CMV Diagnosis Treatment and Considerations on Vaccine-Mediated Prevention 1 Patterns of CMV acquisition vary

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• Infectious disease expert consult
• Considerations on vaccine mediated prevention
• Breast milk
• Viral infection
• Emerging issues and controversies
• Neonatal fungal infections
• The neonatologist
• Ccurrent issues in the pathogenesis
• Treatment of neonatal thrombocytopenia
• Nonhematopoietic effects of erythropoietin
• Coagulation disorders