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Lecture Principles of biochemistry - Chapter 22 (part 1): Protein synthesis

After studying this chapter you will be able to know the genetic code is degenerate and non-overlapping, know the initiation and termination codons, understand the principles behind the third base wobble, know the important structural features of the tRNA, know which base of the anticodon is effected by the 3rd base wobble,. | Chapter 22 (Part 1) Protein Synthesis tRNAs tRNAs are interpreters of the genetic code Length = 73 – 95 bases Have extensive 2o structure Acceptor arm – position where amino acid attached Anticodon – complementary to mRNA Several covalently modified bases Gray bases are conserved between tRNAs tRNAs: 2o vs 3o Structure Aminoacyladenylate Formation Aminoacyl-tRNA Synthetase Rxn | Chapter 22 (Part 1) Protein Synthesis tRNAs tRNAs are interpreters of the genetic code Length = 73 – 95 bases Have extensive 2o structure Acceptor arm – position where amino acid attached Anticodon – complementary to mRNA Several covalently modified bases Gray bases are conserved between tRNAs tRNAs: 2o vs 3o Structure Aminoacyladenylate Formation Aminoacyl-tRNA Synthetase . | Chapter 22 (Part 1) Protein Synthesis tRNAs tRNAs are interpreters of the genetic code Length = 73 – 95 bases Have extensive 2o structure Acceptor arm – position where amino acid attached Anticodon – complementary to mRNA Several covalently modified bases Gray bases are conserved between tRNAs tRNAs: 2o vs 3o Structure Aminoacyladenylate Formation Aminoacyl-tRNA Synthetase Rxn | Chapter 22 (Part 1) Protein Synthesis tRNAs tRNAs are interpreters of the genetic code Length = 73 – 95 bases Have extensive 2o structure Acceptor arm – position where amino acid attached Anticodon – complementary to mRNA Several covalently modified bases Gray bases are conserved between tRNAs tRNAs: 2o vs 3o Structure Aminoacyladenylate Formation Aminoacyl-tRNA Synthetase . | Chapter 22 (Part 1) Protein Synthesis tRNAs tRNAs are interpreters of the genetic code Length = 73 – 95 bases Have extensive 2o structure Acceptor arm – position where amino acid attached Anticodon – complementary to mRNA Several covalently modified bases Gray bases are conserved between tRNAs tRNAs: 2o vs 3o Structure Aminoacyladenylate Formation Aminoacyl-tRNA Synthetase Rxn