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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Computer simulation allows goal-oriented mechanical ventilation in acute respiratory distress syndrome. | Available online http ccforum.eom content 11 2 R36 Research Computer simulation allows goal-oriented mechanical ventilation in acute respiratory distress syndrome Leif Uttman Helena Ogren Lisbet Niklason Bjorn Drefeldt and Bjorn Jonson Department of Clinical Physiology Lund University 221 85 Lund Sweden Corresponding author Leif Uttman leif.uttman@med.lu.se Received 8 Jan 2007 Revisions requested 31 Jan 2007 Revisions received 21 Feb 2007 Accepted 1 2 Mar 2007 Published 1 2 Mar 2007 Critical Care 2007 11 R36 doi 10.1186 cc5719 This article is online at http ccforum.com content 11 2 R36 2007 Uttman et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction To prevent further lung damage in patients with acute respiratory distress syndrome ARDS it is important to avoid overdistension and cyclic opening and closing of atelectatic alveoli. Previous studies have demonstrated protective effects of using low tidal volume VT moderate positive end-expiratory pressure and low airway pressure. Aspiration of dead space ASPIDS allows a reduction in VT by eliminating dead space in the tracheal tube and tubing. We hypothesized that by applying goal-orientated ventilation based on iterative computer simulation VT can be reduced at high respiratory rate and much further reduced during ASPIDS without compromising gas exchange or causing high airway pressure. Methods ARDS was induced in eight pigs by surfactant perturbation and ventilator-induced lung injury. Ventilator resetting guided by computer simulation was then performed aiming at minimal VT plateau pressure 30 cmH2O and isocapnia first by only increasing respiratory rate and then by using ASPIDS as well. Results VT decreased from 7.2 0.5 ml kg to 6.6 0.5