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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Association between neuroserpin and molecular markers of brain damage in patients with acute ischemic stroke | Rodríguez-González et al. Journal of Translational Medicine 2011 9 58 http www.translational-medicine.eom content 9 1 58 JOURNAL OF TRANSLATIONAL MEDICINE RESEARCH Open Access Association between neuroserpin and molecular markers of brain damage in patients with acute ischemic stroke 11 12 1 Raquel Rodríguez-González Tomás Sobrino Manuel Rodríguez-Yánez Mónica Millán David Brea 3 14 3 1 2 1 Elena Miranda Octavio Moldes Juan Pérez David A Lomas Rogelio Leira Antoni Dávalos and José Castillo Abstract Background Neuroserpin has shown neuroprotective effects in animal models of cerebral ischemia and has been associated with functional outcome after ischemic stroke. Our aim was to study whether neuroserpin serum levels could be associated to biomarkers of excitotoxicity inflammation and blood brain barrier disruption. Methods We prospectively included 129 patients with ischemic stroke 58.1 male mean age 72.4 9.6 years not treated with tPA within 12 hours h of symptoms onset mean time 4.7 2.1 h . Poor functional outcome at 3 months was considered as a modified Rankin scale score 2. Serum levels of neuroserpin Interleukin 6 IL-6 Intercellular adhesion molecule-1 ICAM-1 active Matrix metalloproteinase 9 MMP-9 and cellular fibronectin cFn determined by ELISA and glutamate determined by HPLC were measured on admission 24 and 72 h. The main variable was considered the decrease of neuroserpin levels within the first 24 h. ROC analysis was used to select the best predictive value for neuroserpin to predict poor functional outcome due to a lack of linearity. Results The decrease of neuroserpin levels within the first 24 h was negatively correlated with serum levels at 24 hours of glutamate r -0.642 IL-6 r -0.678 ICAM-1 r -0.345 MMP-9 r -0.554 and cFn r -0.703 all P 0.0001 . In the multivariate analysis serum levels of glutamate OR 1.04 CI95 1.01-1.06 p 0.001 IL-6 OR 1.4 CI95 1.1-1.7 p 0.001 and cFn OR 1.3 CI95 1.1-1.6 p 0.002 were independently associated with a decrease of .
