TAILIEUCHUNG - Báo cáo sinh học: "Association between plasma metabolites and gene expression profiles in five porcine endocrine tissues"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học quốc tế đề tài: Association between plasma metabolites and gene expression profiles in five porcine endocrine tissues | Yang et al. Genetics Selection Evolution 2011 43 28 http content 43 1 28 GSE Ge n et i cs Selection Evolution RESEARCH Open Access Association between plasma metabolites and gene expression profiles in five porcine endocrine tissues Bin Yang1 2 3 Anna Bassols4 Yolanda Saco4 and Miguel Perez-Enciso1 2 5 Abstract Background Endocrine tissues play a fundamental role in maintaining homeostasis of plasma metabolites such as non-esterified fatty acids and glucose the levels of which reflect the energy balance or the health status of animals. However the relationship between the transcriptome of endocrine tissues and plasma metabolites has been poorly studied. Methods We determined the blood levels of 12 plasma metabolites in 27 pigs belonging to five breeds each breed consisting of both females and males. The transcriptome of five endocrine tissues . hypothalamus adenohypophysis thyroid gland gonads and backfat tissues from 16 out of the 27 pigs was also determined. Sex and breed effects on the 12 plasma metabolites were investigated and associations between genes expressed in the five endocrine tissues and the 12 plasma metabolites measured were analyzed. A probeset was defined as a quantitative trait transcript QTT when its association with a particular metabolic trait achieved a nominal P value . Results A larger than expected number of QTT was found for non-esterified fatty acids and alanine aminotransferase in at least two tissues. The associations were highly tissue-specific. The QTT within the tissues were divided into co-expression network modules enriched for genes in Kyoto Encyclopedia of Genes and Genomes or gene ontology categories that are related to the physiological functions of the corresponding tissues. We also explored a multi-tissue co-expression network using QTT for non-esterified fatty acids from the five tissues and found that a module enriched in hypothalamus QTT was positioned at the centre of the entire multi-tissue .

• Báo cáo khoa học
• Báo cáo sinh học hay
• cách trình bày báo cáo
• báo cáo sinh học
• công trình nghiên cứu sinh học
• tài liệu về sinh học