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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Biocompatibility of hydrophilic silica-coated CdTe quantum dots and magnetic nanoparticles | Ruan et al. Nanoscale Research Letters 2011 6 299 http www.nanoscalereslett.eom content 6 1 299 o Nanoscale Research Letters a SpringerOpen Journal NANO EXPRESS Open Access Biocompatibility of hydrophilic silica-coated CdTe quantum dots and magnetic nanoparticles Jing Ruanf Kan Wang1 Hua Song Xin Xu Jiajia Ji and Daxiang Cui Abstract Fluorescent magnetic nanoparticles exhibit great application prospects in biomedical engineering. Herein we reported the effects of hydrophilic silica-coated CdTe quantum dots and magnetic nanoparticles FMNPs on human embryonic kidney 293 HEK293 cells and mice with the aim of investigating their biocompatibility. FMNPs with 150 nm in diameter were prepared and characterized by high-resolution transmission electron microscopy and photoluminescence PL spectra and magnetometer. HEK293 cells were cultured with different doses of FMNPs 20 50 and 100p g ml for 1-4 days. Cell viability and adhesion ability were analyzed by CCK8 method and Western blotting. 30 mice were randomly divided into three groups and were respectively injected via tail vein with 20 60 and 100 pg FMNPs and then were respectively raised for 1 7 and 30 days then their lifespan important organs and blood biochemical parameters were analyzed. Results show that the prepared water-soluble FMNPs had high fluorescent and magnetic properties less than 50 pg ml of FMNPs exhibited good biocompatibility to HEK293 cells the cell viability and adhesion ability were similar to the control HEK293 cells. FMNPs primarily accumulated in those organs such as lung liver and spleen. Lung exposed to FMNPs displayed a dose-dependent inflammatory response blood biochemical parameters such as white blood cell count WBC alanine aminotransferase ALT and aspartate aminotransferase AST displayed significant increase when the FMNPs were injected into mice at dose of 100pg. In conclusion FMNPs exhibit good biocompatibility to cells under the dose of less than 50 pg ml and to mice under the dose of .
