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Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí hóa hoc quốc tế đề tài : Red blood cell transfusion in the critically ill patient | Lelubre and Vincent Annals of Intensive Care 2011 1 43 http www.annalsofintensivecare.eom content 1 1 43 Ù Annals of Intensive Care a SpringerOpen Journal REVIEW Open Access Red blood cell transfusion in the critically ill patient Christophe Lelubre and Jean-Louis Vincent Abstract Red blood cell RBC transfusion is a common intervention in intensive care unit ICU patients. Anemia is frequent in this population and is associated with poor outcomes especially in patients with ischemic heart disease. Although blood transfusions are generally given to improve tissue oxygenation they do not systematically increase oxygen consumption and effects on oxygen delivery are not always very impressive. Blood transfusion may be lifesaving in some circumstances but many studies have reported increased morbidity and mortality in transfused patients. This review focuses on some important aspects of RBC transfusion in the ICU including physiologic considerations a brief description of serious infectious and noninfectious hazards of transfusion and the effects of RBC storage lesions. Emphasis is placed on the importance of personalizing blood transfusion according to physiological endpoints rather than arbitrary thresholds. Introduction Red blood cell RBC transfusion is commonly required in critically ill patients. Several recent observational multicenter studies reported that approximately one third of critically ill patients received a blood transfusion at one time or another during their stay in the intensive care unit ICU Table 1 . Because of the frequent use of this intervention it is important for the ICU physician to be aware of recent developments in this continuously evolving field of medicine. In this narrative review we consider some key aspects of transfusion medicine in the ICU focusing on aspects relevant to the critically ill patient including prevalence and reasons for blood transfusion epidemiology and etiology of anemia in these patients pathophysiological .
