Đang chuẩn bị nút TẢI XUỐNG, xin hãy chờ
Tải xuống
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Detection of inflammatory bowel disease by proton magnetic resonance spectroscopy (1H MRS) using an animal model. | Journal of Inflammation BioMed Central Research Open Access Detection of inflammatory bowel disease by proton magnetic resonance spectroscopy H MRS using an animal model Sonal Varma1 2 Ranjana Bird3 Michael Eskin2 Brion Dolenko1 Jayadev Raju3 and Tedros Bezabeh 1 2 Address 1National Research Council Institute for Biodiagnostics Winnipeg Canada 2Department of Human Nutritional Sciences University of Manitoba Winnipeg Canada and 3Department of Biology University of Waterloo Waterloo Canada Email Sonal Varma - sonal.davda@nrc-cnrc.gc.ca Ranjana Bird - rpbird@admmail.uwaterloo.ca Michael Eskin - eskin@cc.umanitoba.ca Brion Dolenko - brion.dolenko@nrc-cnrc.gc.ca Jayadev Raju - jayadev_raju@hc-sc.gc.ca Tedros Bezabeh - tedros.bezabeh@nrc-cnrc.gc.ca Corresponding author Published 26 November 2007 Received 18 July 2007 Accepted 26 November 2007 Journal of Inflammation 2007 4 24 doi 10.1186 1476-9255-4-24 This article is available from http www.journal-inflammation.com content 4 1 24 2007 Varma et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The aim of this study was to analyze the potential of proton magnetic resonance spectroscopy 1H MRS in diagnosing early inflammatory bowel disease IBD . Methods Thirty male Sprague Dawley rats were fed 2 carrageenan in their diet for either 1 or 2 weeks. 1H MRS was performed ex-vivo on colonic mucosal samples n 123 and the spectra were analyzed by a multivariate method of analysis. The results of the multivariate analysis were correlated with histological analysis performed using H E stain for the presence of inflammation in the samples from each group. Results Multivariate analysis classified the samples in their respective groups with an accuracy of 82 . Our region .
