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Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Transdermal opioids for cancer pain | BioMed Central Health and Quality of Life Outcomes Review Transdermal opioids for cancer pain Tracy L Skaer Open Access Address College of Pharmacy Washington State University Wegner Hall Room 105 PO BOX 646510 Pullman WA 99164-6510 USA Email Tracy L Skaer - tskaer@wsu.edu Corresponding author Published 31 March 2006 Received 24 February 2006 Health and Quality of Life Outcomes 2006 4 24 doi 10.1186 1477-7525-4-24 Accepted 31 March 2006 This article is available from http www.hqlo.cOm content 4 1 24 2006 Skaer licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Patients with moderate to severe malignancy-related pain frequently require the use of opioid pharmacotherapy. Unfortunately many cancer patients continue to be prescribed subtherapeutic doses of pain medications resulting in undo suffering and diminished quality of life. The choice of analgesic pharmacotherapy should be individualized and based on the intensity and etiology of pain reported by the patient. Health care providers must be able to readily quantify the relative analgesic potency when converting from one opioid to another or from one route of administration to another. Transdermal fentanyl is effective and well tolerated pharmacotherapy for the cancer pain patients. However clinicians need to be cognizant that the U.S. U.K. manufacturer s recommendations for equilalagesic dosing of transdermal fentanyl may result in initial doses that produce subtherapeutic levels and unrelieved pain in some patients. A more aggressive dosing algorithm for transdermal fentanyl using a 2 1 mg day of oral morphine mcg hr of transdermal fentanyl conversion ratio that considers both a review of the literature and clinical experience should help clinicians individualize .
