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Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Nutrition and inflammation serum biomarkers are associated with 12-week mortality among malnourished adults initiating antiretroviral therapy in Zambia | Koethe et al. Journal of the International AIDS Society 2011 14 19 http www.jiasociety.Org content 14 1 19 JOURNALOF THE INTERNATIONAL AIDS SOCIETY RESEARCH Open Access Nutrition and inflammation serum biomarkers are associated with 12-week mortality among malnourished adults initiating antiretroviral therapy in Zambia I f I . D IX z Z R Z 1 3K ỉ r Z I z l Ỉ - R D I Z x n r-2 4 R r I r 1 z R r f l I 1 v zd s 1 5 E zd ZZ f zd IX Z t s m Z 8 D z Ĩ E c R r R rw zd4 John R Koethe ivieiiQiin Blevins cnrisiopnei NyirenQd EQmonQ K Kdbdgdmbe Bryan t Bnepnera A illHm A oci or2 3 6 IC2 2C 7I ill I1 5 Hnalla M r l iÌTỉcorTỉ9 I Ir A i d R KAi Ilonnsi1 5 AlHciri k lbvunriri7 fiiH C vviiiidm wester Isddc Zulu Jdneiie M diidseid Lioya B Muiengd Albert Mwdngo dnQ Douglas C Heimburger1 2 3 10 Abstract Background A low body mdss index BMI dt dntiretrovirdl therdpy ART initidtion is d strong predictor of mortdlity dmong HIV-infecteQ dQults in resource-constrdineQ settings. The reldtionship between nutrition dnQ infldmmdtion-reldteQ serum biomdrkers dnQ edrly tredtment outcomes e.g. less thdn 90 Qdys in this populdtion is not well QescribeQ. Methods An observdtiondl cohort of 142 HIV-infecteQ dQults in Lusdkd Zdmbid with BMI unQer 16 kg m2 or CD4 lymphocyte counts of less thdn 50 cells mm3 or both wds followeQ prospectively Quring the first 12 weeks of ART. Bdseline dnQ seridl post-tredtment phosphdte dlbumin ferritin dnQ highly sensitive C-redctive protein hsCRP serum levels were medsureQ. The primdry outcome wds mortdlity. Results Lower bdseline phosphdte dnQ dlbumin serum levels dnQ higher ferritin dnQ hsCRP were significdntly dssocidteQ with mortdlity prior to 12 weeks p 0.05 for dll compdrisons inQepenQent of known risk fdctors for edrly ART-dssocidteQ mortdlity in sub-Sdhdrdn Africd. The time-QepenQent intervdl chdnge in dlbumin wds dssocidteQ with mortdlity dfter dQjusting for the bdseline vdlue AHR 0.62 0.43 0.89 per 5 g L incredse but chdnges in the other biomdrkers were not.
