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Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Chloroquine is a potent inhibitor of SARS coronavirus infection and spread | Virology Journal BioMed Central Research Open Access Chloroquine is a potent inhibitor of SARS coronavirus infection and spread Martin J Vincent1 Eric Bergeron2 Suzanne Benjannet2 Bobbie R Erickson1 Pierre E Rollin1 Thomas G Ksiazek1 Nabil G Seidah2 and Stuart T Nichol 1 Address 1Special Pathogens Brach Division of Viral and Rickettsial Diseases Centers for Disease Control and Prevention 1600 Clifton Road Atlanta Georgia 30333 USA and 2Laboratory of Biochemical Neuroendocrinology Clinical Research Institute of Montreal 110 Pine Ave West Montreal QCH2W1R7 Canada Email Martin J Vincent - mvincent@cdc.gov Eric Bergeron - bergere@ircm.qc.ca Suzanne Benjannet - benjans@ircm.qc.ca Bobbie R Erickson - BErickson1@cdc.gov Pierre E Rollin - PRollin@cdc.gov Thomas G Ksiazek - TKsiazek@cdc.gov Nabil G Seidah - seidahn@ircm.qc.ca StuartT Nichol - SNichol@cdc.gov Corresponding author Published 22 August 2005 Received 12 July 2005 Accepted 22 August 2005 Virology Journal 2005 2 69 doi l0.ll86 l 743-422X-2-69 This article is available from http www.virologyj.cOm content 2 1 69 2005 Vincent et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Severe acute respiratory syndrome SARS is caused by a newly discovered coronavirus SARS-CoV . No effective prophylactic or post-exposure therapy is currently available. Results We report however that chloroquine has strong antiviral effects on SARS-CoV infection of primate cells. These inhibitory effects are observed when the cells are treated with the drug either before or after exposure to the virus suggesting both prophylactic and therapeutic advantage. In addition to the well-known functions of chloroquine such as elevations of endosomal pH the drug appears to interfere with .
