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Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Liver-spleen axis, insulin-like growth factor-(IGF)-I axis and fat mass in overweight/obese females | Savastano et al. Journal of Translational Medicine 2011 9 136 http www.translational-medicine.eom content 9 1 136 JOURNAL OF TRANSLATIONAL MEDICINE RESEARCH Open Access Liver-spleen axis insulin-like growth factor- IGF -I axis and fat mass in overweight obese females 1 2 1 1 1 1 Silvia Savastano Carolina Di Somma Genoveffa Pizza Annalba De Rosa Valeria Nedi Annalisa Rossi Francesco Orio3 Gaetano Lombardi1 Annamaria Colao1 and Giovanni Tarantino4 Abstract Background Fat mass FM in overweight obese subjects has a primary role in determining low-grade chronic inflammation and in turn insulin resistance IR and ectopic lipid storage within the liver. Obesity aging and FM influence the growth hormone insulin-like growth factor IGF -I axis and chronic inflammation might reduce IGF-I signaling. Altered IGF-I axis is frequently observed in patients with Hepatic steatosis HS . We tested the hypothesis that FM or spleen volume and C-reactive protein CRP -all indexes of chronic inflammation-could affect the IGF-I axis status in overweight obese independently of HS. Methods The study population included 48 overweight obese women age 41 13 years BMI 35.8 5.8 kg m2 range 25.3-53.7 who underwent assessment of fasting plasma glucose and insulin homeostasis model assessment of insulin resistance HOMA cholesterol and triglycerides HDL-cholesterol transaminases high-sensitive CRP uric acid IGF-I IGF binding protein BP -1 IGFBP-3 and IGF-I IGFBP-3 ratio. Standard deviation score of IGF-I according to age zSDS were also calculated. FM was determined by bioelectrical impedance analysis. HS severity grading score 0-4 according liver hyperechogenicity and spleen longitudinal diameter SLD were evaluated by ultrasound. Results Metabolic syndrome MS and HS were present in 33 and 85 of subjects respectively. MS prevalence was 43 in subjects with increased SLD. IGF-I values but not IGF-I zSDS and IGF-I IGFBP-3 ratio were significantly lower while FM FPI HOMA ALT CRP were significantly higher in
