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Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy improves survival of gastric cancer with peritoneal carcinomatosis: evidence from an experimental study | Tang et al. Journal of Translational Medicine 2011 9 53 http www.translational-medicine.eom content 9 1 53 JOURNAL OF TRANSLATIONAL MEDICINE RESEARCH Open Access Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy improves survival of gastric cancer with peritoneal carcinomatosis evidence from an experimental study 1 t 1 t 1 1 r 7l1 2 1 Li Tang Lie-Jun Mei Xiao-Jun Yang Chao-Qun Huang Yun-Feng Zhou Yutaka Yonemura and Yan Li Abstract Background Cytoreductive surgery CRS plus hyperthermic intraperitoneal chemotherapy HIPEC has been considered as a promising treatment modality for gastric cancer with peritoneal carcinomatosis PC . However there have also been many debates regarding the efficacy and safety of this new approach. Results from experimental animal model study could help provide reliable information. This study was to investigate the safety and efficacy of CRS HIPEC to treat gastric cancer with PC in a rabbit model. Methods VX2 tumor cells were injected into the gastric submucosa of 42 male New Zealand rabbits using a laparotomic implantation technique to construct rabbit model of gastric cancer with PC. The rabbits were randomized into control group n 14 CRS alone group n 14 and CRS HIPEC group n 14 . The control group was observed for natural course of disease progression. Treatments were started on day 9 after tumor cells inoculation including maximal removal of tumor nodules in CRS alone group and maximal CRS plus heperthermic intraperitoneal chemoperfusion with docetaxel 10 mg rabbit and carboplatin 40 mg rabbit at 42.0 0.5 C for 30 min in CRS HIPEC group. The primary endpoint was overall survival OS . The secondary endpoints were body weight biochemistry major organ functions and serious adverse events SAE . Results Rabbit model of gastric cancer with PC was successfully established in all animals. The clinicopathological features of the model were similar to human gastric PC. The median OS was 24.0 d 95 confidence interval 21.8 .
