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Tham khảo tài liệu 'báo cáo hóa học: " carlow virus, a 2002 gii.4 variant norovirus strain from ireland"', luận văn - báo cáo phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | Virology Journal BioMed Central Research Carlow Virus a 2002 GII.4 variant Norovirus strain from Ireland Karen Kearney John Menton and John G Morgan Open Access Address Lab 439 Department of Microbiology University College Cork College Road Cork Ireland Email Karen Kearney - kearney_karen@hotmail.com John Menton - johnmenton@oceanfree.net John G Morgan - j.morgan@ucc.ie Corresponding author Published 13 June 2007 Received 10 April 2007 Accepted 13 June 2007 Virology Journal 2007 4 61 doi 10.1186 1743-422X-4-61 This article is available from http www.virologyj.cOm content 4 1 61 2007 Kearney et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Noroviruses are the leading cause of infectious non-bacterial gastroenteritis in Ireland population 4 million . Due to the number of outbreaks its massive impact on the Irish health service and its seasonality Norovirus has gained public notoriety as The Winter Vomiting Bug. The increase in cases in Ireland in the 2002-2003 season coincided with the emergence of two new Genogroup II genotype 4 variant clusters of Norovirus worldwide. Results Little research has been done on the epidemiology or molecular biology of Norovirus strains in Ireland. In an effort to combat this discrepancy we cloned a full length human norovirus genome as a cDNA clone J3 which can produce full length transcripts in vitro. A polymerase mutant cDNA clone X1 in addition to a sub genomic cDNA clone 1A were produced for use in future work. Carlow virus Hu NoV GII Carlow 2002 Ire genome is 7559 nts in length excluding the 3-end poly A tail and represents the first Norovirus strain from Ireland to be sequenced. Conclusion Carlow virus is a member of the Farmington Hills variant cluster of .
