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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Rhabdomyolysis: a manifestation of cyclobenzaprine toxicity | Journal of Occupational Medicine and Toxicology BioMed Central Open Access Case report Rhabdomyolysis a manifestation of cyclobenzaprine toxicity Shiven B Chabria Address Division of Hospital Medicine Dept. of Internal Medicine Waterbury Hospital Waterbury CT USA Email Shiven B Chabria - shivenchabria@yahoo.com Corresponding author Published 17 July 2006 Received 02 May 2006 Journal of Occupational Medicine and Toxicology 2006 1 16 doi 10.1186 1745-6673-1-16 Accepted I7 July 2006 This article is available from http www.occup-med.cOm content 1 1 16 2006 Chabria licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract A case of cyclobenzaprine flexeril overdose and the resultant rhabdomyolysis is presented. A review of the range of clinical toxicity management of overdose is described. The similarity of cyclobenzaprine to the tricyclic antidepressant class is emphasized this report attempts to disseminate related information on this commonly prescribed centrally acting muscle relaxant. Background Cyclobenzaprine flexeril after its synthesis in 1961 was found to have limited antidepressant action with no significant advantage over other tricyclic antidepressants 1 . However it was found to act as a centrally acting muscle relaxant and has been widely used ever since. Muscle relaxants account for approximately 18.5 of all prescriptions written for chronic back pain in the United States 2 . We present this case as an example of the range of cyclobenzaprine toxicity and underline the treatment protocols used. Case report A 33 year old male was brought into the emergency room after reportedly ingesting approximately 30 pills of 10 mg each of cyclobenzaprine flexeril about 2 hours prior in attempt to commit suicide. Vital signs on
