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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Soluble HLA measurement in saliva and cerebrospinal fluid in Caucasian patients with multiple sclerosis: a preliminary study | Journal of Neuroinflammation BioMed Central Research Open Access Soluble HLA measurement in saliva and cerebrospinal fluid in Caucasian patients with multiple sclerosis a preliminary study Irena Adamashvili1 Alireza Minagar1 Eduardo Gonzalez-Toledo2 Liubov Featherston1 and Roger E Kelley 1 Address Department of Neurology LSU Health Sciences Center 1501 Kings Highway Shreveport LA 71130 USA and 2Department of Radiology LSU Health Sciences Center 1501 Kings Highway Shreveport LA 71130 USA Email Irena Adamashvili - IAdama@lsuhsc.edu Alireza Minagar - aminag@lsuhsc.edu Eduardo Gonzalez-Toledo - egonz1@lsuhsc.edu Liubov Featherston - lfeath@lsuhsc.edu Roger E Kelley - rkelly@lsuhsc.edu Corresponding author Published 02 June 2005 Received 09 May 2005 Journal of Neuroinflammation 2005 2 13 doi l0.ll86 1742-2094-2-13 Accepted 02 June 2005 This article is available from http www.jneuroinflammation.cOm content 2 1 1 3 2005 Adamashvili et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Measurement of soluble HLA in body fluids has a potential role in assessing disease activity in autoimmune disorders. Methods We applied a solid phase enzyme-linked immunoassay to measure soluble HLA class I sHLA-I and class II sHLA-II molecules in the saliva and cerebrospinal fluid CSF in 13 untreated patients with relapsing-remitting form of multiple sclerosis MS . For comparison purposes we also studied saliva from 53 healthy subjects. Results Saliva from normal controls had detectable sHLA-I levels in 41 of 53 individuals studied with values ranging from 9-100 ng ml mean 41 2.8 ng ml . sHLA-I was undetectable in the saliva in 11 of 13 MS patients and in none of the CSF specimens. In contrast mean sHLA-II concentration in the .
