Đang chuẩn bị nút TẢI XUỐNG, xin hãy chờ
Tải xuống
The aim of this study was to assess the effects of Pomelo (Citrus grandis (L.) Osbeck) peel extracts (CGE) on activity of lipid-carbohydrate metabolic enzymes such as Carnitine pamitoyl-transferase (CPT), lipase, hexokinase, glucose 6-phosphatase and blood lipid glucose parameters in experimental obese and diabetic mice. The results showed that, in the experimental obese mice treated daily, orally with CGE at dose of 1200 mg/body weight for three weeks, | VNU Journal of Science Natural Sciences and Technology 26 2010 224-232 Effect of pomelo citrus grandis l . osbeck peel extract on lipid-carbohydrate metabolic enzymes and blood lipid glucose parameters in experimental obese and diabetic mice Do Ngoc Lien1 . Nguyen Thi Thuy Quynh1 Do Van Phuc1 Vu Cong Phong2 Phung Thanh Huong3 1 Faculty of Biology College of Science VNU 334 Nguyen Trai Hanoi Vietnam 2Pedagogical University of Ha Noi No-2 3Hanoi University of Pharmacy Received 18 January 2010 Abstract. The aim of this study was to assess the effects of Pomelo Citrus grandis L. Osbeck peel extracts CGE on activity of lipid-carbohydrate metabolic enzymes such as Carnitine pamitoyl-transferase CPT lipase hexokinase glucose 6-phosphatase and blood lipid glucose parameters in experimental obese and diabetic mice. The results showed that in the experimental obese mice treated daily orally with CGE at dose of 1200 mg body weight for three weeks activity of hepatic CPT have been raised from 30.5 for ethanol extract to 63.3 for ethyl acetate extract compared to the control. Simultaneous increase of blood lipolytic activity was demonstrated in obese mice treated daily by CGE in comparison with the control. In addition body weight reducing and hypolipidemic effect of the CGE in obese mice were proven clearly. Interestingly the anti-diabetic effect of CGE in diabetic STZ induced mice was demonstrated. Fasting blood glucose levels in diabetic mice treated orally with CGE 1200 mg kg.b.w for three weeks were reduced clearly in comparison with the control diabetic mice untreated p 0.001 . Especially hepatic hexokinase activity in diabetic mice treated with CGE was raised from 14.19 for ethanol extract to 55.46 for ethyl acetate extract in comparison with the control untreated diabetic mice . On the contrary activity of hepatic glucose 6-phosphatase in treated diabetic mice was decreased clearly as compared to untreated diabetic mice p 0.05 . Keywords Citrus grandis L. Obeck blood .
