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Table 84-2 Definition of TNM–Nasopharynx Primary Tumor (T) Stage Grouping TX Cannot assessed be 0 Stage Tis N0 M0 T0 No evidence I Stage T1 N0 M0 Tis Carcinoma in situ IIA Stage T2a N0 M0 T1 Tumor confined IIB Stage T1 N1 M0 to the nasopharynx T2 Tumor extends to soft tissues T2 N1 M0 T2a extends to Tumor the T2a N1 M0 oropharynx and/or nasal cavity parapharyngeal extension w/o T2b Any tumor with extension parapharyngeal T2b N1 M0 T3 Tumor involves T2b N1 M0 bony structures and/or paranasal sinuses T4 Tumor intracranial with extension III Stage T1 N2 M0 and/or involvement of cranial infratemporal nerves, fossa, T2a N2 M0 hypopharynx, orbit, or masticator space Regional (N) Lymph Nodes T2b N2 M0 The distribution and the prognostic lymph impact node of spread regional from T3 . | Chapter 084. Head and Neck Cancer Part 4 Table 84-2 Definition of TNMâ Nasopharynx Primary Tumor T Stage Grouping TX Cannot be assessed Stage 0 Tis N0 M0 T0 No evidence Stage I T1 N0 M0 Tis Carcinoma in situ Stage IIA T2a N0 M0 T1 Tumor confined to the nasopharynx Stage IIB T1 N1 M0 T2 Tumor extends to soft tissues T2 N1 M0 T2a Tumor extends to the oropharynx and or nasal cavity w o parapharyngeal extension T2a N1 M0 T2b Any tumor with parapharyngeal extension T2b N1 M0 T3 Tumor involves bony structures and or paranasal sinuses T2b N1 M0 T4 Tumor with intracranial extension and or involvement of cranial nerves infratemporal fossa hypopharynx orbit or masticator space Stage III T1 N2 M0 T2a N2 M0 Regional Lymph Nodes N T2b N2 M0 The distribution and the prognostic impact of regional lymph node spread from nasopharynx cancer particularly of the undifferentiated type are different from those of other head and neck mucosal cancers and justify the use of a different N classification scheme. T3 N0 .