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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: The encapsulation effect of UV molecular absorbers into biocompatible lipid nanoparticles | Lacatusu et al. Nanoscale Research Letters 2011 6 73 http www.nanoscalereslett.eom content 6 1 73 o Nanoscale Research Letters a SpringerOpen Journal NANO EXPRESS Open Access The encapsulation effect of UV molecular absorbers into biocompatible lipid nanoparticles loana Lacatusu Nicoleta Badea Alina Murariu Aurelia Meghea Abstract The efficiency of a cosmetic product depends not only on the active ingredients but also on the carrier system devoted to improve its bioavailability. This article aims to encapsulate two couples of UV molecular absorbers with a blocking action on both UV-A and UV-B domains into efficient lipid nanoparticles. The effect of encapsulation on the specific properties such as sun protection factor and photostability behaviour has been demonstrated. The lipid nanoparticles with size range 30-350 nm and a polydispersity index between 0.217 and 0.244 are obtained using a modified high shear homogenisation method. The nanoparticles had spherical shapes with a single crystallisation form of lipid matrices characteristic for the least ordered crystal structure a-form . The in vitro determination of photoprotection has led to high SPF ratings with values of about 20 which assure a good photoprotection and filtering about 95 of UV radiation. The photoprotection effect after irradiation stage was observed to be increased more than twice compared to initial samples as a result of isomerisation phenomena. All the results have shown that good photoprotection effect and improved photostability could be obtained using such sunscreen couples thus demonstrating that UV absorbers-solid lipid nanoparticles are promising carriers for cosmetic formulations. Introduction The methodologies for nanoparticles synthesis represent a promising approach which may be used to develop new biocompatible carrier systems for various compounds with lipophil character such as UV chemical absorbers and applications in cosmetic field. The der-mato-cosmetic products with .
