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Chapter 5 - Linkage, recombination and the mapping of genes on chromosomes. This chapter includes contents: Gene linkage and recombination, the chi-square test and linkage analysis, recombination: a result of crossing-over during meiosis, mapping: locating genes along a chromosome, tetrad analysis in fungi, mitotic recombination and genetic mosaics. | Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display PowerPoint to accompany Genetics: From Genes to Genomes Fourth Edition Leland H. Hartwell, Leroy Hood, Michael L. Goldberg, Ann E. Reynolds, and Lee M. Silver Prepared by Mary A. Bedell University of Georgia Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display Hartwell et al., 4th ed., Chapter 5 CHAPTER Basic Principles: How Traits Are Transmitted CHAPTER PART I Linkage, Recombination and the Mapping of Genes on Chromosomes 5.1 Gene Linkage and Recombination 5.2 The Chi-Square Test and Linkage Analysis 5.3 Recombination: A Result of Crossing-Over During Meiosis 5.4 Mapping: Locating Genes Along a Chromosome 5.5 Tetrad Analysis in Fungi 5.6 Mitotic Recombination and Genetic Mosaics CHAPTER OUTLINE Gene linkage and recombination Genes linked together on the same chromosome usually assort together Linked genes may become separated by recombination Two themes in this chapter: Further apart two genes are, the greater the probability of recombination Recombination data can be used to generate maps of relative locations of genes on chromosomes Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display Hartwell et al., 4th ed., Chapter 5 Detecting linkage by analyzing the progeny of dihybrid crosses: X-linked genes Syntenic genes – genes located on the same chromosome Two X-linked genes in Drosophila with recessive alleles w+ (red eyes) and w (white eyes) y+ (brown body) and y (yellow body) Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display Hartwell et al., 4th ed., Chapter 5 Note that in this cross: F1 males get their only X chromosome from their mothers F1 females are dihybrids Fig. 5.2a Detecting linkage by analyzing the progeny of dihybrid crosses: X-linked genes (cont) Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or . | Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display PowerPoint to accompany Genetics: From Genes to Genomes Fourth Edition Leland H. Hartwell, Leroy Hood, Michael L. Goldberg, Ann E. Reynolds, and Lee M. Silver Prepared by Mary A. Bedell University of Georgia Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display Hartwell et al., 4th ed., Chapter 5 CHAPTER Basic Principles: How Traits Are Transmitted CHAPTER PART I Linkage, Recombination and the Mapping of Genes on Chromosomes 5.1 Gene Linkage and Recombination 5.2 The Chi-Square Test and Linkage Analysis 5.3 Recombination: A Result of Crossing-Over During Meiosis 5.4 Mapping: Locating Genes Along a Chromosome 5.5 Tetrad Analysis in Fungi 5.6 Mitotic Recombination and Genetic Mosaics CHAPTER OUTLINE Gene linkage and recombination Genes linked together on the same chromosome usually assort together Linked genes may become separated by recombination Two
