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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Effect of mesoporous silica under Neisseria meningitidis transformation process: environmental effects under meningococci transformation | Hollanda et al. Journal of Nanobiotechnology 2011 9 28 http www.jnanobiotechnology.eom content 9 1 28 JOURNAL OF NANOBIOTECHNOLOGY SHORT COMMUNICATION Open Access Effect of mesoporous silica under Neisseria meningitidis transformation process environmental effects under meningococci transformation 1 I z-z z- 1 1 2 2 2 Luciana M Hollands Gisele CG Cury Rafaella FC Pereira Gracielle A Ferreira Andreza Sousa Edesia MB Sousa and Marcelo Lancellotti1 Abstract Background This study aimed the use of mesoporous silica under the naturally transformable Neisseria meningitidis an important pathogen implicated in the genetic horizontal transfer of DNA causing a escape of the principal vaccination measures worldwide by the capsular switching process. This study verified the effects of mesoporous silica under N. meningitidis transformation specifically under the capsular replacement. Methods we used three different mesoporous silica particles to verify their action in N. meningitis transformation frequency. Results we verified the increase in the capsular gene replacement of this bacterium with the three mesoporous silica nanoparticles. Conclusion the mesouporous silica particles were capable of increasing the capsule replacement frequency in N. meningitidis. Findings Freshly isolated Neisseria meningitidis are naturally competent and exchange genetic information with each other by this process. They are also known as a commensal bacterium of the human upper respiratory tract that may occasionally provoke invasive infections such as septicemia and meningitis. This natural competence has been directly correlated to pilliation of these organisms 1 as well as a specific uptake sequence contained multifold within the genome of these bacteria. Pilliated strains are easily transformed by direct incubation with a plasmid containing the uptake sequence or chromosomal DNA 2 . The advantages of doing genetic manipulations within these well-known strains are numerous. Development of .
