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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Effect of arginase II on L-arginine depletion and cell growth in murine cell lines of renal cell carcinoma | BioMed Central Journal of Hematology Oncology Research Effect of arginase II on L-arginine depletion and cell growth in murine cell lines of renal cell carcinoma David J Tate Jr1 Derek J Vonderhaar1 Yupanqui A Caldas2 Toye Metoyer3 John R Patterson IV1 Diego H Aviles4 and Arnold H Zea 1 5 Address Stanley S. Scott Cancer Center LSUHSC New Orleans USA 2Division of Renal Diseases and Hypertension UCDHSC Denver Colorado USA 3Morehouse School of Medicine Atlanta GA USA 4Division of Pediatric Nephrology Children s Hospital New Orleans LA USA and 5Microbiology Immunology and Parasitology LSUHSC New Orleans LA USA Email David J Tate - dtate1@lsuhsc.edu Derek J Vonderhaar - dvonde@lsuhsc.edu Yupanqui A Caldas - yupanqui.caldas@uchsc.edu Toye Metoyer - tmetoyer@msm.edu John R Patterson - jpatt3@lsuhsc.edu Diego H Aviles - davile@lsuhsc.edu Arnold H Zea - azea@lsuhsc.edu Corresponding author Open Access Published 25 September 2008 Received 29 July 2008 Accepted 25 September 2008 Journal of Hematology Oncology 2008 1 14 doi 10.1186 1756-8722-1-14 This article is available from http www.jhoonline.Org content 1 1 14 2008 Tate et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background L-arginine is the common substrate for the two isoforms of arginase. Arginase I highly expressed in the liver and arginase II mainly expressed in the kidney. Arginase I-producing myeloid derived suppressor cells have been shown to inhibit T-cell function by the depletion of L-arginine. On the other hand arginase II has been detected in patients with cancer and is thought to metabolize L-arginine to L-ornithine needed to sustain rapid tumor growth however its role in L-arginine depletion is unclear. Thus in tumor biology L-arginine metabolism .
