Đang chuẩn bị nút TẢI XUỐNG, xin hãy chờ
Tải xuống
Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Passage and concentration-dependent effects of Indomethacin on tendon derived cells | Journal of Orthopaedic Surgery and Research BioMed Central Research article Passage and concentration-dependent effects of Indomethacin on tendon derived cells Emad Mallick Nanette Scutt Andy Scutt and Christer Rolf Address Sheffield Centre Of Sports Medicine School Of Medicine Biomedical Sciences Beech Hill Road Sheffield S10 2RS UK Email Emad Mallick - dremad_smap@yahoo.com Nanette Scutt - n.scutt@sheffield.ac.uk Andy Scutt - a.m.scutt@sheffield.ac.uk Christer Rolf-c.g.rolf@sheffield.ac.uk Corresponding author Open Access Published 2 April 2009 Received 11 June 2008 Journal of Orthopaedic Surgery and Research 2009 4 9 doi 10.1186 1749-799X-4-9 Accepted 2 April 2009 This article is available from http www.josr-online.com content 4 1 9 2009 Mallick et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.Org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Non-steroidal anti-inflammatory drugs NSAID are commonly used in the treatment of tendinopathies such as tendonitis and tendinosis. Despite this little is known of their direct actions on tendon-derived cells. As NSAIDs have been shown to delay healing in a number of mesenchymal tissues we have investigated the direct effects of indomethacin on the proliferation of tendon-derived cells. Results and Discussion The results obtained were dependent on both the type of cells used and the method of measurement. When measured using the Alamar blue assay a common method for the measurement of cell proliferation and viability no effect of indomethacin was seen regardless of cell source. It is likely that this lack of effect was due to a paucity of mitochondrial enzymes in tendon cells. However when cell number was .
