Đang chuẩn bị nút TẢI XUỐNG, xin hãy chờ
Tải xuống
During the following session of the Institute, Professor Rosa lectured “with dignity upon the principles of Homeopathy” as was declared by the whole class, “notwithstanding the many embarrassments appendaged thereunto.” As a result, a few students were won over to Homeopathy, though the majority of the class remained Eclectic. At the Commencement, held March 6, 1850, six students received both Eclectic and Homeopathic diplomas. Thus was the Eclectic Medical Institute the first institution in the West to give Homeopathic instruction, and the first in the West to graduate a class in Homeopathy. In this class was the distinguished Homeopathic historian | ARTICLE IN PRESS EJINME-02029 No of Pages 7 European Journal of Internal Medicine xxx 2011 xxx-xxx Contents lists available at ScienceDirect European Journal of Internal Medicine journal homepage www.elsevier.com locate ejim Review article Nutrition and Alzheimer s disease The detrimental role of a high carbohydrate diet Stephanie Seneffa Glyn Wainwrightb Luca Mascitellic a Department of Electrical Engineering and Computer Science Mư Cambridge MA USA b Independent Reader of Research Leeds United Kingdom c Comando Brigata alpina Julia Medical Service 8 Via S. Agostino Udine 33100 Italy ARTICLE INFO ABSTRACT Article history Received 29 October 2010 Received in revised form 8 December 2010 Accepted 27 December 2010 Available online xxxx Keywords Advanced glycation end-products Alzheimer s disease Cholesterol Alzheimer s disease is a devastating disease whose recent increase in incidence rates has broad implications for rising health care costs. Huge amounts of research money are currently being invested in seeking the underlying cause with corresponding progress in understanding the disease progression. In this paper we highlight how an excess of dietary carbohydrates particularly fructose alongside a relative deficiency in dietary fats and cholesterol may lead to the development of Alzheimer s disease. A first step in the pathophysiology of the disease is represented by advanced glycation end-products in crucial plasma proteins concerned with fat cholesterol and oxygen transport. This leads to cholesterol deficiency in neurons which significantly impairs their ability to function. Over time a cascade response leads to impaired glutamate signaling increased oxidative damage mitochondrial and lysosomal dysfunction increased risk to microbial infection and ultimately apoptosis. Other neurodegenerative diseases share many properties with Alzheimer s disease and may also be due in large part to this same underlying cause. 2011 European Federation of Internal Medicine. .
