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Ví dụ về các sản phẩm tự nhiên hoạt tính sinh học từ Menispermaceae gia đình. 8,2 ARCANGELINA Flava (L.) Merr. [: Latin flavus = màu vàng tinh khiết.] 8.2.1 Thực vật học Arcangelina Flava (L.) Merr. (Arcangelisia lemniscata Miers Becc.) Là một người leo núi lớn phát triển trong các khu rừng mưa của Thái Lan | PHAN TẤT HOÀ --- NHỮNG CÂY TI H OC CHÂU Á THÁI BÌNH DƯƠNG 38 Copy rig ht K 2 6 T ay I ũ r t r ra nd s G rnụp I I i Picrotoxinin OCH3 O H3C N OHH3C O N - - CH3 OH H3CO -Tubocurarine Figure 8.1 Examples of bioactive natural products from the family Menispermaceae. 8.2 ARCANGELINA FLAVA L. MERR. From Latin flavus pure yellow. 8.2.1 Botany Arcangelina flava L. Merr. Arcangelisia lemniscata Miers Becc. is a large climber that grows in the rain forests of Thailand Malaysia Indonesia and the Philippines. The stems are 4mm large at the apex smooth and glabrous. The petiole is 3.5-9cm long. The leaves are simple exstipulate and spiral. The blade is 7cm X 4cm - 7.5cm X 13cm elliptic acuminate at the apex thick and recurved. The inflorescences are axillary and have 6cm-long panicles. The flowers are white. The fruits are globose 3.5cm X 2.3cm - 2.5cm X 1.5cm fleshy yellow drupes Figure 8.2 . 8.2.2 Ethnopharmacology The plant is known as mengkunyit bukit in Indonesia where a decoction of stems is used as a drink to treat jaundice indigestion and painful bowels. The wood is used to heal pox sores. In the Philippines a decoction of roots Buy now from http www.drugswell.com is used as a drink to reduce fever to invigorate to promote menses and to abort and a decoction of wood is used as an antiseptic for the skin. Cutting fresh stems of this climber reveals a bright yellowish-orange color which is accounted for by isoquinoline alkaloids berberine jatrorrhizine dihydroberberine and palmatine which abound in it Figure 8.3 . Berberine inhibits the growth of HepG2 cells by direct interaction with DNA in PHAN TẤT HOÀ --- NHỮNG CÂY TI H OC CHÂU Á THÁI BÌNH DƯƠNG 39 which it intercalates.1 This intercalating property of berberine and congeners explains the broad range of antibacterial and Í opy rig lit 2 6 r ay I Ũ r t r ra nci s J roup I Li OCH3 Palmatine Jatrorrhizine Figure 8.2 Arcangelina flava L. Merr. From Phytochemical Survey of the Federation of Malaya. KL No 1615. July 21 1959.
