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In recent years, the remarkable advances in medical imaging instruments have increased their use considerably for diagnostics as well as planning and follow-up of treatment. Emerging from the fields of radiology, medical physics and engineering, medical imaging no longer simply deals with the technology and interpretation of radiographic images. The limitless possibilities presented by computer science and technology, coupled with engineering advances in signal processing, optics and nuclear medicine have created the vastly expanded field of medical imaging. The Handbook of Medical Imaging is the first comprehensive compilation of the concepts and techniques used to analyze and manipulate medical images. | HANDBOOK OF MEDICAL IMAGING Editorial Advisory Board Dr. William Brody President Johns Hopkins University Dr. Elias Zerhouni Chairman Department of Radiology and Radiological Science Johns Hopkins Medical Institutions Section Editors Dr. Rangaraj M. Rangayyan Department of Electrical and Computer Engineering University of Calgary Dr. Roger p. Woods Division of Brain Mapping UCLA School of Medicine Dr. Richard A. Robb Director Biomedical Imaging Resource Mayo Foundation Dr. H. K. Huang Department of Radiology Childrens Hospital of Los Angeles University of Southern California Academic Press Series in Biomedical Engineering Joseph Bronzino Series Editor The focus of this series will be twofold. First the series will produce a set of core text references for biomedical engineering undergraduate and graduate courses. With biomedical engineers coming from a variety of engineering and biomedical backgrounds it will be necessary to create new cross-disciplinary teaching and self-study books. Secondly the series will also develop handbooks for each of the major subject areas of biomedical engineering. Joseph Bronzino the series editor is one of the most renowned biomedical engineers in the world. He is the Vernon Roosa Professor of Applied Science at Trinity College in Hartford Connecticut. HANDBOOK OF MEDICAL IMAGING PROCESSING AND ANALYSIS EDITOR-IN-CHIEF ISAAC N. BANKMAN PhD APPLIED PHYSICS LABORATORY JOHNS HOPKINS UNIVERSITY LAUREL MARYLAND ACADEMIC PRESS A Horcociit Science and Technology Com pnny SAN DIEGO SAN FRANCISCO NEW YORK BOSTON LONDON SYDNEY .