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Pharmaceutical Substances Syntheses, Patents, Applications - Part 134. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Midodrine M 1331 0 0 n CHjOH. H2O ------ ----- Midecamycin acetate Reference s DE 2 004 686 Meiji prior. 3.2.1970 . US 3 761 588 Meiji 25.9.1973 J-pnor. 25.9.1969 . DOS 2 835 547 Meiji appl. 14.8.1978 J-prior 15.8.1977 . DOS 2 537 375 Meiji appl. 22.8.1975 J-prior 27.8 1974 US 4 017 607 Meiji 12.4.1977 J-prior. 27.8.1974 . US 4 188 480 Meiji 12.2.1980 J-prior. 15.8.1977 . Omoto s. et al. J. Antibiot. JANTAJ 24 536 1976 . Nakamura K. et al. Chem. Lett. CMLTAG 1978 1293. Formulation s tabl. 400 mg Trade Name s F Mosil Menarini I Macroral Malesci 1985 Miocamen Menarini J 1985 Miokacin Firma 1986 Miocamycin Meiji Seika 1985 Midodrine ATC C01CA17 Use antihypotensive a-adrenergic vasoconstrictor RN 97476-58-9 MF C12H18N2O4 MW 254.29 CN -2-amino-lV- 2- 2 5-dimethoxyphenyl -2-hydroxyethyl acetamide monohydrochloride RN 3092-17-9 MF C12H18N2O4 HC1 MW 290.75 LD50 56.2 mg kg M Í.V. 246 mg kg M p.o. 18.2 mg kg R Í.V. 68.8 mg kg R p.o. 150 mg kg dog p.o. 2-omino-2 5 -di- methoxyocetophenone . Q CI CI chloroacetyl chloride 1 sodium azide NaBH4 Pd-C sodium borohydride Reference DAS 2 523 735 Lentia appl. 28.5.1975 A-prior. 24.7.1974 . alternative syntheses AT241 435 Österr. Stickstoffwerke Linz appl. 11.6.1963 valid from 15.12.1964 . DOS 2 506 110 Lentia appl. 13.2.1975 . BE 838 512 Chemie Linz AG appl. 12.8.1976 D-prior. 13.2.1975 . 1332 M Midoriamin Formulation s amp. 5 mg drops 10 mg ml tabl. 2.5 mg 5 mg as hydrochloride Trade Name s D Gutron Nycomed F Gutron Nycomed SA I Gutron Guidotti J Metligine Taisho USA ProAmatine Roberts Midoriamin ATC A02B Thiamine cobaltichlorophylline complex J sc ulcer tlleraPeutic RN 87211-44-7 MF C4 H53CoN8O9S MW 952.98 LD 0 209 mg kg M i.p. 3066 mg kg M p.o. 406 mg kg M s.c. 82 mg kg R i.p. 3590 mg kg R p.o. 201 mg kg R s.c. CN OC-6-24- 25 -rranj - 7V- 4-amino-2-methyl-5-pyrimidinyl methyl -A- 4-hydroxy-2-mercapto-l- methyl-l-butenyl formamide aqua 18-carboxy-20- carboxymethyl -8-ethenyl-13-ethyl-2 3-dihydro- 3 7 12 17-tetramethyl-2177 23 .
