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Pharmaceutical Substances Syntheses, Patents, Applications - Part 181. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers. | Reserpine R 1801 Reference s US2974 144 Riker 7.3.1961 appl. 1954 prior. 1953 . US 2 876 228 Pfizer 3.3.1959 appl. 1956 . Klohs M.W. et al. J. Am. Chem. Soc. JACSAT 77 2241 1955 . partial synthesis from reserpic acid methyl ester US 2 854 454 P. R. Ulshafer 1958 appl. 1954 . Formulation s tabl. 0.25 mg 0.5 mg Trade Name s Detensitral Karlspharma - Sarparel Servier -comb. Caniramine Hokuriku comb. wfm wfm Cinnaloid Taito Pfizer Diuraupur Guilini -comb. Tensid Bayer Pharma - Colstamin Kowa Kowa wfm comb. wfm Daisaloid Mohan Rauwopur Giulini -comb. Tensitral Dausse -comb. Isocalsin Kowa Yakuhin wfm wfm Rescinate Ohta Aldatense Searle -comb. Tensitral Synthélabo - Resiloid Nippon Shoji wfm comb. wfm Rozex Teisan Anaprel F Servier -comb. I Resertan Perkins -comb. Sciminan Kotani wfm wfm Seripinin Fuji Zoki Diviator Servier -comb. J Apolon Toyama Sinselpin Kobayashi wfm Aporecin Kayaku USA Moderil Pfizer wfm Atension Santen Reserpine atc C02AA02 Use antihypertensive tranquilizer RN 50-55-5 MF C H40N2O9 MW 608.69 EINECS 200-047-9 LD50 21 mg kg M i.v. 200 mg kg M p.o. 15 mg kg R i.v. 420 mg kg R p.o. 500 pg kg dog i.v. CN 3ß 16ß 17ct 18ß 20a -11 17-dimethoxy-18- 3 4 5-trimethoxybenzoyl oxy Jyohimban-16-carboxylic acid methyl ester By extraction of the roots of Rauwolfia serpentina L. Beuth. Reference s DE 967 469 Boehringer Ing. appl. 1954 . US 2 752 351 Ciba 1956 appl. 1953 . US 2 833 771 Ciba 1958 CH-Frior. 1954 . US 2 887 489 Ciba 1959 CH-prior. 1956 . US 2 938 906 Ciba 1960 CH-prior. 1952 . Dorfmann L. et al. Helv. Chim. Acta HCACAV 37 59 1954 . Ullmanns Encykl. Tech. Chem. 4. Aufl. Vol. 7 178. Ullmanns Encykl. Tech. Chem. 3. Aufl. Vol. 13 277. i 1802 R Retinol total synthesis DAS 1 088 062 Research Corp. appl. 3.5.1957 USA-prior. 3.5.1956 . Hanessian S et al. J. Org. Chem. JOCEAH 62 465 1997 . Formulation s cps. 0.075 mg 0.15 mg drg. 0.05 mg 0.07 mg 0.1 mg tabl. 0.1 mg 0.125 mg 0.25 mg Trade Name s D Adelphan-Esidrix Novartis Resaltex Procter Serpasil Esidrex Ciba - .