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Pharmaceutical Substances Syntheses, Patents, Applications - Part 209. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers. | Torasemide T 2081 Reference s Kingsbury W.D. et al. J. Med. Chcm. JMCMAR 34 1 98 1991 . EP 321 122 SmithKline Beecham appl. 30.11.1988 USA-prior. 1.12.1987 . W09 205 785 SmithKline Beecham appl. 23.9.1991 USA-prior. 28.9.1990 . Formulationfs vial 4 mg as hydrochloride Trade Name s D Hycamtin SmithKline GB Hycamtin SmithKline USA Hycamtin SmithKline Beecham F Hycamtin SmithKline I Beecham Beecham Beecham Hycamtin SmithKline Beecham Torasemide AC 4464 BM 02015 Use antihypertensive loop diuretic RN 56211-40-6 MF C16H20N4O3S MW 348.43 CN A TMethylethyl amino carbonyl -4 3-methylphcnyl amino -3-pyridinesulfonamide sodium salt RN 72810-59-4 MF C16H2oN403S xNa MW unspecified OH pci5 POCIi 4-chloropyridine- 3-sulfanamtde II 4-hydroxy-pyridine m-taluidine HI 3- sulfanomido- 4- 3-methylanilino - pyridine IV CH TEA 95 C IV OCN --------- isopropyl isocyanate V Torasemide TEA 0 I Cl O H H III Cu 95 C ch3 ------------- Torasemide 1 -isopropyl-3- 4-chlor0- 3-pyridylsulfonyl ureo 2082 T Toremifene Reference s a bDelarge J. Arzneim.-Forsch. ARZNAD 38 I la 1988 . DE 2 516 025 A. Christiaens appl. 12.4.1975 GB-prior. 17.4.1974 . stable crystalline modification DE 3 623 620 Boehringer Mannheim appl. 17.8.1985 D-prior. 17.8.1985 . injections containing torasemide DE 3 623 620 Boehringer Mannheim D-prior. 12.7.1986 . rapidly disintegrating pellets WO 09 810 754 Boehringer Mannheim appl. 9.9.1997 D-prior. 12.9.1996 . polymorphism and control of the serum solubility of orally administered torasemide US 5 914 336 Boehringer Mannheim 22.6.1999 USA-prior. 2.6.1998 . tablets containing torasemide WO 9 300 097 Boehringer Mannheim appl. 25.6.1992 J-prior. 25.6.1991 . use for treatment of brain edema DE 4 113 820 Boehringer Mannheim D-prior. 27.4.1991 . Formulation s amp. 10.631 mg 2 ml 21.262 mg 4 ml 212.62 mg 20 ml as sodium salt tabl 2.5 mg 5mg 10 mg Trade Name s D Torem Berlin-Chemie Unat Roche 1999 Toremifene ATC L02BA02 FC-1157a Use antiestrogen antineoplastic RN 89778-26-7 MF C26H28C1NO .
