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Pharmaceutical Substances Syntheses, Patents, Applications - Part 207. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers. | Tizanidine T 2061 Tizanidine ATC MO3BXO2 Use skeletal muscle relaxant RN 51322-75-9 MF C9H8C1N5S MW 253.72 LD50 235 mg kg M p.o. 600 mg kg R p.o. CN 5-chloro- V- 4 5-dihydro-lH-imidazol-2-yl -2 l 3-benzothiadiazol-4-amine hydrochloride RN 64461-82-1 MF C9H8C1N5S HC1 MW 290.18 SOCIj DMF A 1. HNO3 H2S04 2. Fe CHjCOOH k Cl2CS ----------- thiophosgene 4-chloro-t 2- 5-chloro-2 1 3- diaminobenzene benzothiadtazole 5-chloro-4- ethylene- isothiacyonato- diamine Pb OCOCH3 2 KOH ------------ lead ll acetate 2 1 3-benzothiadiazole Reference s DE 2 322 880 Sandoz appl. 22.11.1973 prior. 7.5.1973 . US 3 843 668 Sandoz 22.10.1974 appl. 8.5.1973 CH-prior. 9.5.1972 . CH 579 565 Sandoz appl. 15.3.1973 . synthesis ö 4-amino-5-chloro-2 l 3-benzothiadiazole Pesin V.G. . Khaletskil A.M. Zh. Obshch. Khim. ZOKHA4 27 2599 1957 . C.A. CHABA8 52 7292. Smith W.T. Chen W.-Y J. Org. Chem. JOCEAH 27 676 1962 . Formulation s tabi. 2 mg 4 mg 6 mg as hydrochloride Trade Name s D Sirdalud Sanofi Winthrop GB Zanaflex Athena 1985 J Teonelin Sandoz USA Zanaflex Athena Tobramycin atc-. JOiGBoi soiaai2 Use antibiotic RN 32986-56-4 MF C18H37N5O9 MW 467.52 EINECS 251-322-5 LD5 72.5 mg kg M i.v. 11500 mg kg M p.o. 104 mg kg R i.v. 7500 mg kg R p.o. CN O-3-amino-3-deoxy-a-D-glucopyranosyl- l 6 -6 - 2 6-diamino-2 3 6-trideoxy-a-D-ribtf-hexopyranosyl- 1 4 -2-deoxy-D-streptamine 2062 T Tobramycin sulfate RN 49842-07-1 MF Cl8H37N5O9 xH2SO4 MW unspecified EINECS 256-499-2 LD5o 77 mg kg M i.v. 10500 mg kg M p.o. 126 mg kg R i.v. from fermentation solutions of Streptomyces tenebrarius ATCC 17920 or ATCC 17921 bekanomycin q. v. ATP E. coli R11 IF0 13560 -------------------------------k adenosine triphosphate 1. H3C 3SiCI H5C6 3P. h3C- S CH3 3 N Si CH3 3 2. Raney-Ni H20 I --------------------------------------------------- 1. trimethylchlorosilone triph enylphasphine. N 0-bis trimethylsilyl ocetamide nh2 I Reference s a US 3 691 279 Lilly 12.9.1972 prior. 15.4.1970 12.2.1969 17.9.1965 . DE 1 792 819 Lilly . b DOS 2
