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Pharmaceutical Substances Syntheses, Patents, Applications - Part 85. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Fenfluramine F 841 monohydrochloride RN 1892-80-4 MF C18H23N5O2 HC1 MW 377.88 EINECS 217-580-8 LD50 55 mg kg M i.v. 347 mg kg M p.o. 100 mg kg R p.o. CH3 7- 2 chloroethyl theophylline 1 -methyl-2-phenylethylamine theophylline phenylacetone Fenetylline Reference s DE 1 123 329 Degussa appl. 18.10.1958 addition to DE 1 095 285 appl. 25.9.1956 . US 3 029 239 Degussa 10.4.1962 D-prior. 17.4.1954 . Formulation s . f. c. tabl. 50 mg as hydrochloride Trade Name s D Captagon ASTA Medica F Captagon Gerda wfm AWD Captagon Promdeica wfm Fenfluramine atc A08AA02 Use appetite depressant anorexic RN 458-24-2 MF C12H16F3N MW 231.26 EINECS 207-276-3 LD50 145 mg kg M p.o. 130 mg kg R p.o. 100 mg kg dog p.o. CN A-ethyl-a-methyl-3- trifluoromethyl benzeneethanamine hydrochloride RN 404-82-0 MF C12H16F3N HC1 MW 267.72 EINECS 206-968-2 LDS0 90 mg kg M i.v. 170 mg kg M p.o. 69 mg kg R p.o. 23 mg kg dog i.v. 100 mg kg dog p.o. 842 F Fenipentol CFj 3-trifluoromethyl-phenyQacetone h2n-oh hydroxylomine 3-trïfluoromethyl-phenyl acetone H2 Raney Ni ------------- cf3 2-omino-1 - 3-trifluoromethyl- oxime phenyQprapone I OHC CH3 acetaldehyde H2 Raney-Ni ------------- Reference s FR-M 1 658 Science-Union appl. 4.4.1961 MC-prior. 5.11.1960 . Formulation s cps. 20 mg 60 mg s. r. cps. 60 mg tabl. 20 mg 40 mg as hydrochloride Trade Name s D Ponderax Boehringer F Ponderal Biopharma as Pesos Valeas Ing. wfm hydrochloride Ponderal Servier Ponderax Itherapia wfm GB I Ponderax Servier wfm Dimafen Stroder USA Pondimin Robins Fenipentol ATC A05AX Use choleretic RN 583-03-9 MF ChH16O MW 164.25 EINECS 209-493-9 LD50 2900 mg kg M p.o. 5432 mg kg R p.o. CN a-butylbenzenemethanol CHO benzaldehyde butylmagnesium bromide Reference s GB 915 815 Thomae appl. 11.4.1960 valid from 6.4.1961 . US 3 084 100 Thomae 2.4.1963 appl. 30.3.1961 . Adams R.M. Vander-Werf C.A. J. Am. Chem. Soc. JACSAT 72 4368 1950 . Engelhorn R. Arzneim.-Forsch. ARZNAD 10 255 1960 . Koss F.W. et al. Arzneim.-Forsch. ARZNAD 12 1026 1962 . .
