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Pharmaceutical Substances Syntheses, Patents, Applications - Part 83. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | F Etymemazine E 821 HjC I N CHO H 1. pocij 2. h2o 4-methoxy-2 3 6-trimethylbenz-aldehyde NoOH --------------k acetone ch3 4- 4-methoxy-2 3 6-trimethylphenyl -3-buten-2-one II acetylene brorn de 111 HBr benzene ------------ IV triphenyl- phosphine Reference s Mayer H. et al. Experientia EXPEAM 34 1105 1978 . US 4 105 681 Roche 8.8.1978 prior. 22.3.1974 1.8.1975 13.8.1976 . DOS 2414 619 Roche appl. 26.3.1974 CH-prior. 30.3.1973 . US 4 215 215 Hoffmann-La Roche 29.7.1980 prior. 6.7.1979 . medical use US4200 647 Hoffmann-LaRoche 29.4.1980 appl. 12.12.1978 CH-prior. 21.12.1977 . Formulation s cps. 10 mg 25 mg Trade Name s D Tigason Roche 1982 wfm F Tigason Roche wfm GB Tigason Roche wfm I Tigason Roche J Tigason Roche USA Tegison Roche 1986 Etymemazine atc roôad Äthylisobutrazin Ethotrimeprazine Ethylisobutrazine Use antihistaminic tranquilizer hypnotic RN 523-54-6 MF C20H26N2S MW 326.51 CN 2-ethyl-N N ß-trimethyl-10H-phenothiazine-10-propanamine 822 E Etynodiol acetate monohydrochloride RN 3737-33-5 MF C20H26N2S HC1 MW 362.97 EINECS 223-111-8 LD50 70 mg kg M i.v. 2-ethyl-phenothiozine 1. NoNH2 xylene 1. sodium amide 2. 3-dimethylcmino-2- methylpropyl chloride Reference s DE 1 034 638 Rhône-Poulenc appl. 1955 F-prior. 1954 . Trade Name s F Nuital Vaillant-Defresnc wfm Etynodiol acetate Àthynodioldiacetat Ethynodiol diacetate Etynodiol diacetate ATC G03AA Use progestogen in combination with estrogen as oral contraceptive RN 297-76-7 MF C24H32O4 MW 384.52 EINECS 206-044-9 CN 3p 17a -19-norpregn-4-en-20-yne-3 17-dioI diacetate norethisterone ocetote q. v. 1. LIAIH . THF CH3 2. OH 1. lithium donate . ethylmethylpropylcarbinol etynodiol I 0 0 pyridine 12 II JÍ ---------------- h3c och3 acetic anhydride U ch3 n c2h5 3 -------------------- triethylomine 4-dimethylamino-pyridine Etynodiol acetóte n F . Exalamide E 823 Reference s a US 3 176 013 Searle 30.3.1965 appl. 25.7.1963 . U DE 1 668 604 Gedeon Richter appl. 7.9.1967 H-prior. 7.9.1969 . i DE 2 137 557 Gedeon Richter appl.
