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Pharmaceutical Substances Syntheses, Patents, Applications - Part 50. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Citrulline C 491 Hepasteril B. compositum forte Fresenius -comb. wfm Mederma Merz -comb. wfm Reducdyn Nordmark -comb. wfm Sterofundin-CH Braun Melsungen wfm Tutofusin LC Pfrimmer wfm F I Thioncycline Merrell -comb. wfm Thioxidrene Bottu wfm Citiolase Roussel Citrulline ATC VO3AB99 Use liver therapeutic RN 372-75-8 MF C6H13N3O3 MW 175.19 EINECS 206-759-6 CN A3- aminocarbonyl -L-ornithine malate 1 1 RN 70796-17-7 MF C6H13N3O3 C4H4O4 MW 291.26 u I H2 H2NyN C0QH HCI 1. NaOH 2. CuO 3. H2S NH L-orginine hydrochloride H H2 h2nyn ä cooh 0 Citrulline 2 by fermentation o from Soccharomyces genus b from ornithine c from Arthrobocter Reference s 1 Fox S.W. J. Biol. Chem. JBCHA3 123 687 1938 . 2a JP52 143 288 Kyowa appl. 20.5.1976 . 2b JP 50 148 588 Miura appl. 23.5.1974 . 2c JP53 075 387 Kyowa appl. 13.12.1976 . alternative syntheses JP 12248 67 Ajinomoto appl. 11.9.1965 . JP 117 58 68 Kyowa appl. 15.11.1965 . Fox S.W. et al. J. Org. Chem. JOCEAH 6 410 1941 . crystallization JP 7 100 174 Ajinomoto appl. 20.11.1968 . isolation from Citrullus vulgaris Schrad. Wada M. Biochem. Z. BIZEA2 224 420 1930 . use as liver therapeutic FR-M 4 182 Inst de Recherche Sei. appl. 9.3.1965 . FR-M 5 594 Dimaphar appl. 1.7.1966 . FR-M 5 703 Lab. Carriere Carron appl. 30.8.1965 . FR-M 6 305 Dimaphar appl. 15.12.1966 . use as digestant FR-M 5 695 Lab. Carriere Carron appl. 29.8.1966 . citrulline fumarate FR-M 6 306 Dimaphar appl. 15.12.1966 . 492 c Cladribine citrulline maleate FR-M 6 443 Dimaphar appl. 21.4.1967 . Formulation s amp. 60 mg 15 ml drg. 25 mg 100 mg Trade Name s D Polilevo Taurus Pharma - comb. F Azonutril Pharmacia Upjohn -comb. Epuram Pharmafarm -comb. Perifago Pharmacia Upjohn Stimol Biocodex as malate I Biotassina UCM -comb. Citruplexina Synthelabo -comb. Ipoazotal SIT -comb. Cladribine NSC-105014-F RWJ-26251 2-CdA ATC L01BB04 Use antineoplastic RN 4291-63-8 MF C 0H12ClN5O3 MW 285.69 CN 2-chloro-2 -deoxyadenosine 2-deoxy-3 5-di-0-p-toluoyl-a-D-erythro-pentofuranosyl chloride NoH .
