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Synthesis, reaction, and evaluation of the anticancer activity of 6,7,8,9-tetrahydro-5H -cyclohepta[4,5]selenopheno[2,3-d]pyrimidine derivatives

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The cyclocondensation of 2-amino-5,6,7,8-tetrahydro-4H -cyclohepta[b] selenophene-3-carbonitrile (1) with formic acid and formamide gave the selenophenopyrimidine 15 and selenophenopyrimidone 6 derivatives. The reaction of 6 with phosphorus oxychloride produced 4-chloro-6,7,8,9-tetrahydro-5H -cyclohepta[4,5] seleno[2,3-d]pyrimidine (12), the key compound for our nucleophilic substitution reactions. |

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