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Dioxin gây ảnh hưởng nghiêm trọng đến sức khỏe con người ngay cả khi hiện diện trong mỡ người ở nồng độ một vài phần ngàn tỷ (ppt). Dioxin là chất hóa học phá hủy mạnh các nội tiết tố. Bằng cách gắn vào thụ thể nội tiết tố của tế bào dẫn đến sự biến đổi cơ chế hoạt động và di truyền của tế bào, gây nên hàng loạt các hiệu ứng xấu: từ ung thư cho đến giảm khả năng miễn dịch, rối loạn hệ thần kinh, sẩy thai và các dị tật bẩm sinh. | Science & Technology Development, Vol 14, No.M1- 2011 PCDD/FS LEVEL IN HUMAN ADIPOSE TISSUE OF BIENHOA RESIDENTS IN COMPARISON WITH DEVELOPED INDUSTRIAL COUNTRIES Mai Tuan Anh Institute of Environment and Resources, VNU-HCM (Manuscript Received on August 31th, 2010, Manuscript Revised March 03rd, 2010) ABSTRACT: Dioxin exhibits serious health effects when it reaches as concentration a few ppt in human body fat. Dioxin is a powerful hormone disrupting chemical. By binding to a cell's hormone receptor, it literally modifies the functioning and genetic mechanism of the cell, causing a wide range of effects, from cancer to reduced immunity, nervous system disorders, miscarriages and birth deformity. Median i-TEQ in adipose tissue of the BienHoa residents is comparable with that of the developed countries while mean i-TEQ of the Bien Hoa residents is higher in both groups, especially older people group. This group has some exceptional cases with i-TEQ value up to 1148.7pg/g. The i-TEQ value in our studies is higher than that conducted by other studies. However, our result supports a conclusion: at present, the dioxin concentration in natural environment and human bodies in Southern Vietnam is only a residue and not higher than that in developed countries. Keywords: Agent Orange, BienHoa, CECOTOX, Dioxin, Furan, Human Adipose, IER, PCDD/Fs, i-TEQ, QuangNgai, QuangNam, Vietnam. Chromosome aberrations in the germ cells (in 1. INTRODUCTION Based on the published researches of many scientists (Cau HD, 2003) , the strong toxicity female, male) might transmit to subsequent generations. of dioxin that after penetrating into the human For above reason, human adipose tissue is body, generates several notorious features on an important matrix to understand the influence congenital anomalies for F1 generation of those of dioxins on human health (especially adipose who were exposed to A.O/Dioxin. Researches tissue of pregnant women because it is directly on bio-genetic
