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Acne is a disorder of the body’s pilosebaceous units. Each unit consists of a sebaceous gland and a canal or follicle, which is lined with cells called keratinocytes and which contains a fine hair. Most numerous in the skin of the face, upper back, and chest, sebaceous glands manufacture an oily substance called sebum, which is released onto the skin’s surface through the follicle’s opening, or pore. All the constituents of the narrow follicle—the hair, sebum, and keratinocytes—may form a plug that prevents the sebum from reaching the surface of the skin through the pore. The plug allows a strain of bacterium, called Propionibacterium acnes, to multiply in the plugged follicle. As bacteria. | DISEASES and DISORDERS 7TCj Marshall Cavendish Reference New York Marshall Cavendish 99 White Plains Road Tarrytown New York 10591 www.marshallcavendish.us 2008 Marshall Cavendish Corporation All rights reserved. No part of this book may be reproduced or utilized in any form or by any means electronic or mechanical including photocopying recording or by any information storage and retrieval system without permission from the copyright holders. Library of Congress Cataloging-in-Publication Data Diseases and disorders p. cm. Includes bibliographical references and index. ISBN 978-0-7614-7770-9 set alk. paper -- ISBN 978-0-7614-7771-6 v. 1 -- ISBN 9780-7614-7772-3 v. 2 -- ISBN 978-0-7614-7774- 7 v.-J 1. Diseases. 2. Medicine. I. Title. RC41.D57 2007 616--dc22 2007060867 Photographic Credits Front Cover Shutterstock Stephen Sweet Alamy Ian Shaw 237 Corbis Paliava Bagla 272 Shawn Frederick 46 John Henley 21 Rainer Jensen DPA 55 Visuals Unlimited 110 Digital Vision 75 190 206 212 Dynamic Graphics 146 239 263 264 Getty Images 253 PHIL 187 CDC Dr. Lyle Conrad 303 CDC Dr. Gordon D. McLaren 49 Sol Silverman Jr. DDS 160 Photodisc 243 266 Photolibrary oSF BSIP 115 120 288 Phototake Inc. 158 Photos.com 76 87 233 Rex Features Fotex 298 Garo Phanie 165 166 Henry K. T Kaiser 17 Image Source 38 Phanie Agency 73 156 Sabah Arar 84 Sipa Press 214 Voisin Phanie 28 147 259 300 Science Photo Library 33 141 221 230 279 Dr. M. A. Ansary 283 Annabella Bluesky 81 BSIP Scott Camazine 217 CNRI 116 Du Cane Medical Imaging Ltd. 226 Eye of Science 270 Dr. Robert Frieland 41 Steve Gschmeissner 136 139 277 Cavallini James 128 Dr. P. Marazzi 254 David M. Martin 280 Andrew McClenaghan 210 Institute of Laryngology and Otology 296 Will and Deni McIntyre 101 MIT AI LAB Surgical Planning Lab Brigham and Women s Hospital 125 Professors P M. Motta and T. Fujita 204 Professors P. M. Motta and F. M. Magliocca 182 Alfred Pasieka 196 John Radcliffe Hospital 133 Science Source 70 Lauren Shear 292 St. .