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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: APOBEC3G encapsidation into HIV-1 virions: which RNA is it. | Retrovirology BioMed Central Commentary APOBEC3G encapsidation into HIV-1 virions which RNA is it Klaus Strebel and Mohammad A Khan Open Access Address Laboratory of Molecular Microbiology National Institute of Allergy and Infectious Diseases National Institutes of Health 4 312 Bethesda MD 20892-0460 USA Email Klaus Strebel - kstrebel@niaid.nih.gov Mohammad A Khan - Mkhan@niaid.nih.gov Corresponding author Published 2 July 2008 Received 11 June 2008 Retrovirology 2008 5 55 doi 10.1186 1742-4690-5-55 Accepted 2 July 2008 This article is available from http www.retrovirology.cOm content 5 1 55 2008 Strebel and Khan licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract APOBEC3G is a cytidine deaminase with potent antiviral activity. The protein deaminates singlestranded DNA but is known to bind cellular and viral RNAs. There is increasing evidence that RNA binding of APOBEC3G is important for packaging into viral particles. However there is no consensus yet on the type of RNA involved. Commentary APOBEC3G is a cytidine deaminase that was recently identified as the prime substrate of the HIV-1 viral infectivity factor Vif 1 . In the absence of Vif APOBEC3G is packaged into viral cores and potently interferes with virus replication for a recent review see 2 . While it is undisputed that much of APOBEC3G s antiviral activity comes from its encapsidation into virions the mechanism of APOBEC3G packaging remains under discussion. Several studies conclude that APOBEC3G packaging is RNA independent and mediated by an APOBEC3G Gag interaction while others identified a requirement for viral or cellular RNA in the APOBEC3G packaging process Figure 1 . The study by Bach et al. 3 attempts to shed light onto the mechanism of APOBEC3G .
