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The Diagnosis and Management of Non-Alcoholic Fatty Liver Disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association

The health of the mother has a profound effect on the health of her children. This effect is most noticeable during pregnancy but persists throughout the child’s life. I concentrate here on the impact of poverty and low income on the relationship between maternal health in pregnancy and during the early years of her child’s life and child health. Poverty in childhood exerts its effect throughout the life course and can be transmitted across generations. Inter- generational transmission occurs through maternal health and health-related behaviour before and during pregnancy. Low birthweight of the mother herself, influenced by the socio-economic status of. | AASLD PRACTICE GUIDELINE The Diagnosis and Management of Non-Alcoholic Fatty Liver Disease Practice Guideline by the American Association for the Study of Liver Diseases American College of Gastroenterology and the American Gastroenterological Association Naga Chalasani MD FACG 1 Zobair Younossi MD FACG 2 Joel E. Lavine MD PhD 3 Anna Mae Diehl MD 4 Elizabeth M. Brunt MD 5 Kenneth Cusi MD 6 Michael Charlton MD 7 and Arun J. Sanyal MD8 Preamble These recommendations are based on the following 1 a formal review and analysis of the recently published world literature on the topic Medline search up to June 2011 2 the American College of Physicians Manual for Assessing Health Practices and Designing Practice Guidelines- 3 guideline policies of the three societies approving this document and 4 the experience of the authors and independent reviewers with regards to NAFLD. Intended for use by physicians and allied health professionals these recommendations suggest preferred approaches to the diagnostic therapeutic and preventive aspects of care. They are intended to be flexible and adjustable for individual patients. Specific recommendations are evidence-based wherever possible and when such evidence is not available or inconsistent recommendations are made based on the consensus opinion of the authors. To best characterize the evidence cited in support of the recommendations the AASLD Practice Guidelines Committee has adopted the classification used by the Grading of Recommendation Assessment Development and Evaluation GRADE workgroup with minor modifications Table 1 .2 The strength of recommendations in the GRADE system is classified as strong 1 or weak 2 . The quality of evidence supporting strong or weak recommendations is designated by one of three levels high A moderate B or low-quality C .2 This is a practice guideline for clinicians rather than a review article and interested readers can refer to several comprehensive reviews published recently.3-8 Definitions The .