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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Managing an effective treatment for neuroleptic malignant syndrome. | Available online http ccforum.eom content 11 1 R4 Research Managing an effective treatment for neuroleptic malignant syndrome Udo Reulbach Carmen Dutsch Teresa Biermann Wolfgang Sperling Norbert Thuerauf Johannes Kornhuber and Stefan Bleich Department of Psychiatry and Psychotherapy Friedrich Alexander University of Erlangen-Nuremberg Schwabachanlage 6 D-91054 Erlangen Germany Corresponding author Udo Reulbach udo.reulbach@psych.imed.uni-erlangen.de Received 13 Sep 2006 Revisions requested 28 Oct 2006 Revisions received 20 Dec 2006 Accepted 1 2 Jan 2007 Published 12 Jan 2007 Critical Care 2007 11 R4 doi 10.1186 cc5148 This article is online at http ccforum.com content 11 1 R4 2007 Reulbach et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Neuroleptic malignant syndrome NMS is a rare but sometimes fatal adverse reaction to neuroleptics characterized principally by fever and rigor. The aim of this study was to prove the efficacy of different NMS treatment strategies focusing on the efficacy of dantrolene. Methods Altogether 271 case reports were included. These cases were categorized into four treatment groups and compared to each other according to effectiveness of therapy within 24 hours mortality complete time of remission in days effectiveness due to increase of dosage relapse on the basis of decrease of dosage and improvement of symptoms. Results Between the four treatment groups the complete time of remission was significantly different analysis of variance F 4.02 degrees of freedom 3 p 0.008 . In a logistic regression with adjustment for age gender and severity code no significant predictor of the treatment for the complete time of remission dichotomized by median could be found.
