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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Late presentation of a mucinous ovarian adenocarcinoma which was initially diagnosed as a primary pancreatic carcinoma: a case report and review of the literature | Papantoniou et al. Journal of Medical Case Reports 2010 4 89 http www.jmedicalcasereports.eom content 4 1 89 jAc JOURNALOF medical ÌỤr case REPORTS CASE REPORT Open Access Reduced uptake of the proliferation-seeking radiotracer technetium-99m-labelled pentavalent dimercaptosuccinic acid in a 47-year-old woman with severe breast epithelial hyperplasia taking ibuprofen a case report Vassilios J Papantoniou1 Evangelia K Sotiropoulou2 Pipitsa N Valsamaki1 Angeliki G Tsaroucha1 fC Or i-f-i rnncii iloi 13 Pi PfoHic4 A i 1 31 Cl fir ll I Cfir iCTi riol li1 Idr ir ici T r li ir ir iC E PimiiTTỉl Tỉl ic5 Maria G Sotiropoulou Nikolaos D Ptohis Aikaterini J Stipsanelli Konstantinos E Dimitrakakis Spyridon G Marinopoulos5 Spyridon T Tsiouris1 Aris J Antsaklis5 Abstract Introduction Recent studies have reported a risk reduction in the progression of benign breast disease to breast carcinoma through COX-2 pathways. Case presentation We present a case of severe epithelial hyperplasia in a 47-year-old woman with increased breast density submitted to scintimammography by the proliferation-imaging tracer Technetium-99m-labelled pentavalent dimercaptosuccinic acid before and after an oral ibuprofen treatment for 4 weeks. The radiotracer uptake after ibuprofen intake was significantly reduced both visually and by semi-quantitative analysis based on a calculation of lesion-to-background ratios. Conclusion In proliferating breast lesions scintigraphically displayed reduction in Technetium-99m-labelled pentavalent dimercaptosuccinic acid uptake may indicate inhibition by ibuprofen in the pathway of malignant epithelial cell transformation. Introduction Several epidemiological and laboratory studies suggest that non-steroidal anti-inflammatory drugs NSAIDs may have chemo-preventive effects in breast cancer owing to their activity against cyclo-oxygenase-2 COX-2 the rate-limiting enzyme in the prostaglandin cascade 1 . Recent studies have suggested that inflammation through COX-2 pathways