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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Procalcitonin testing has the potential to reduce unnecessary antibiotic use in patients with suspected lower respiratory tract infections. | Available online at http ccforum.eom content 9 3 E5 University of Pittsburgh Department of Critical Care Medicine Evidence-Based Medicine Journal Club EBM Journal Club Section Editor Eric B. Milbrandt MD MPH Journal club critique Procalcitonin testing has the potential to reduce unnecessary antibiotic use in patients with suspected lower respiratory tract infections Sadiq Al-Nakeeb1 and Gilles Clermont2 1 Clinical Fellow Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA 2 Assistant Professor Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA Published online 17 February 2005 Critical Care2005 9 E5 DOI 10.1186 cc3496 This article is online at http ccforum.com content 9 3 E5 2005 BioMed Central Ltd Expanded Abstract Citation Christ-Crain M Jaccard-Stolz D Bingisser R Gencay MM Huber PR Tamm M Muller B Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections cluster-randomized single-blinded intervention trial. Lancet 2004 363 600-607.1 Background Lower respiratory tract infections are often treated with antibiotics without evidence of clinically relevant bacterial disease. Serum calcitonin precursor concentrations including procalcitonin are raised in bacterial infections but not in viral infections. Hypothesis Procalcitonin PCT -guided treatment of suspected lower respiratory tract infection substantially reduces antibiotic use without compromising clinical or laboratory outcomes. Methods Design Prospective cluster-randomized controlled singleblinded intervention trial. Setting Medical emergency department of a 784-bed academic tertiary care hospital in Basel Switzerland. Subjects 243 patients presenting to the emergency department who were admitted with suspected lower respiratory tract infection as the main diagnosis. Intervention Patients were randomly assigned to either standard care n 199 or .