Đang chuẩn bị nút TẢI XUỐNG, xin hãy chờ
Tải xuống
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Post heat shock tolerance: a neuroimmunological anti-inflammatory phenomenon. | Journal of Inflammation BioMed Central Hypothesis Post heat shock tolerance a neuroimmunological anti-inflammatory phenomenon Shahram Shahabi 1 Zuhair M Hassan2 and Nima Hosseini Jazani1 Open Access Address Department of Microbiology Immunology and Genetics Faculty of Medicine Urmia University of Medical Sciences Urmia Iran and 2Department of Immunology School of Medical Sciences Tarbiat Modarres University Tehran Iran Email Shahram Shahabi - shahabirabori@yahoo.com Zuhair M Hassan - hassan_zm@yahoo.co.uk Nima Hosseini Jazani - n_jazani@yahoo.com Corresponding author Published 27 March 2009 Journal of Inflammation 2009 6 7 doi 10.1 186 1476-9255-6-7 Received 22 December 2008 Accepted 27 March 2009 This article is available from http www.journal-inflammation.cOm content 6 1 7 2009 Shahabi et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract We previously showed that the progression of burn-induced injury was inhibited by exposing the peripheral area of injured skin to sublethal hyperthermia following the burn. We called this phenomenon post-heat shock tolerance. Here we suggest a mechanism for this phenomenon. Exposure of the peripheral primary hyperalgesic allodynic area of burned skin to local hyperthermia 45 C 30 seconds which is a non-painful stimulus for normal skin results in a painful sensation transmitted by nociceptors. This hyperthermia is too mild to induce any tissue injury but it does result in pain due to burn-induced hyperalgesia allodynia. This mild painful stimulus can result in the induction of descending anti-nociceptive mechanisms especially in the adjacent burned area. Some of these inhibitory mechanisms such as alterations of sympathetic outflow and the production of endogenous opioids can .