TAILIEUCHUNG - Báo cáo y học: " Treatment of candidemia and invasive candidiasis in the intensive care unit: post hoc analysis of a randomized, controlled trial comparing micafungin and liposomal amphotericin "

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Treatment of candidemia and invasive candidiasis in the intensive care unit: post hoc analysis of a randomized, controlled trial comparing micafungin and liposomal amphotericin B. | Available online http content 13 5 R159 Research Treatment of candidemia and invasive candidiasis in the intensive care unit post hoc analysis of a randomized controlled trial comparing micafungin and liposomal amphotericin B Bertrand F Dupont1 Olivier Lortholary1 2 Luis Ostrosky-Zeichner3 Flavie Stucker4 and Vijay Yeldandi5 1Université Paris Descartes Hôpital Necker-Enfants Malades Centre d Infectiologie Necker-Pasteur 149 rue de Sevres 75015 Paris France 2Centre National de Reference Mycologie et Antifongiques Institut Pasteur CNRS URA3012 25 rue du Docteur Roux 75724 Paris France 3University of Texas 6431 Fannin St John Freeman Building Houston TX 77030 USA 4Astellas Pharma BV Elisabethhof 19 2353 EW Leiderdorp The Netherlands 5Westlake Hospital 1111 Superior Street SUITE 101 Melrose Park IL 60160 USA Corresponding author Bertrand F Dupont Received 10 Jul 2009 Revisions requested 29 Jul 2009 Revisions received 27 Aug 2009 Accepted 5 Oct 2009 Published 5 Oct 2009 Critical Care 2009 13 R159 doi cc8117 This article is online at http content 13 5 R159 2009 Dupont et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Invasive candidiasis and candidemia are lifethreatening nosocomial infections in intensive care patients. Methods A post hoc analysis of a phase 3 trial assessing micafungin 100 mg day for subjects 40 kg 2 mg kg day for subjects 40 kg versus liposomal amphotericin B 3 mg kg day . Subgroups were defined according to the type of ward on the first day of treatment intensive care unit ICU or non-ICU. Multivariate regression was performed to identify factors associated with treatment success at end of therapy and allcause .

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