Đang chuẩn bị nút TẢI XUỐNG, xin hãy chờ
Tải xuống
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: The influence of N-acetyl-L-cystein infusion on cytokine levels and gastric intramucosal pH during severe sepsis. | Available online http ccforum.eom content 8 4 R1 72 Research The influence of M-acetyl-L-cystein infusion on cytokine levels and gastric intramucosal pH during severe sepsis Sayim Emet1 Dilek Memis2 and Zafer Pamukọu3 Open Access Department of Anaesthesiology and Reanimation Medical Faculty Trakya University Edirne Turkey 2Associate Professor Department of Anaesthesiology and Reanimation Medical Faculty Trakya University Edirne Turkey 3Professor Chair of Department of Anaesthesiology and Reanimation Medical Faculty Trakya University Edirne Turkey Corresponding author Dilek Memiậ dilmemis@mynet.com Received 23 December 2003 Revisions requested 25 January 2004 Revisions received 27 February 2004 Accepted 20 April 2004 Published 14 May 2004 Critical Care 2004 8 R172-R1 79 DOI 10.1186 cc2866 This article is online at http ccforum.com content 8 4 R172 2004 Emet et al. licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Introduction The purpose of the present study was to evaluate the effects of continuously infused N-acetyl-L-cystein NAC on serum cytokine levels and gastric intramucosal pH in humans suffering from severe sepsis. Methods Fifty-three patients were included in the study. In the NAC group n 27 after an initial intravenous bolus of NAC 150 mg kg over 5 min a continuous intravenous infusion of 12.5 mg kg per hour was given for 6 hours. Patients in the control group n 26 were administered dextrose 5 solution at the same dosage. We recorded the following haemodynamic parameters nasopharyngeal temperature arterial blood gas changes plasma cytokine levels biochemical parameters intramucosal pH length of stay in the intensive care unit duration of of mechanical ventilation and mortality. All measurements were taken at baseline 15 min before the start of the study and were repeated .
