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Báo cáo y học: " Activation of the SPHK/S1P signalling pathway is coupled to muscarinic receptor-dependent regulation of peripheral airways"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Activation of the SPHK/S1P signalling pathway is coupled to muscarinic receptor-dependent regulation of peripheral airways. | Respiratory Research BioMed Central Research Open Access Activation of the SPHK SIP signalling pathway is coupled to muscarinic receptor-dependent regulation of peripheral airways Melanie Pfaff1 Norbert Powaga1 Sibel Akinci1 Werner Schutz1 Yoshiko Banno2 Silke Wiegand1 Wolfgang Kummer1 Jurgen Wess3 and Rainer Viktor Haberberger 1 Address Institute for Anatomy and Cell Biology Justus-Liebig-University Giessen Germany 2Department of Cell Signaling Graduate School of Medicine Gifu University Gifu Japan and 3Laboratory of Bioorganic Chemistry National Institute of Diabetes and Digestive Kidney Diseases Bethesda Maryland 20892 USA Email Melanie Pfaff - Mel.pfaff@gmx.de Norbert Powaga - Norbert.powaga@web.de Sibel Akinci - Sibel.akinci@web.de Werner Schutz - Werner-schuetz@web.de Yoshiko Banno - banno@cc.gifu-u.ac.jp Silke Wiegand - Silke.wiegand@anatomie.med.uni-giessen.de Wolfgang Kummer - Wolfgang.kummer@anatomie.med.uni-giessen.de Jurgen Wess - jwess@helix.nih.gov Rainer Viktor Haberberger - Rainer.v.haberberger@anatomie.med.uni-giessen.de Corresponding author Published 31 May 2005 Received 12 November 2004 Respiratory Research 2005 6 48 doi 10.1186 1465-9921 -6-48 Accepted 3 I May 2005 This article is available from http respiratory-research.cOm content 6 1 48 2005 Pfaff et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background In peripheral airways acetylcholine induces contraction via activation of muscarinic M2-and M3-receptor subtypes M2R and M3R . Cholinergic hypersensitivity is associated with chronic obstructive pulmonary disease and asthma and therefore the identification of muscarinic signaling pathways are of great therapeutic interest. A pathway that has been shown to be activated via MR and to .